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Merck
CN

8.43943

Propanephosphonic acid anhydride

(50% solution in 2-Methyltetrahydrofuran) for synthesis T3P

Synonym(s):

2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide solution, PPACA, Propylphosphonic anhydride, T3P

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About This Item

NACRES:
NA.22
UNSPSC Code:
12352108
Form:
liquid
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Quality Level

form

liquid

bp

78-80 °C/1013 hPa (solvent)

transition temp

flash point -11 °C (solvent)

density

1.039 g/cm3 at 20 °C

storage temp.

2-8°C

Application


  • Study on the propylphosphonic anhydride (T3P) mediated Ugi-type three-component reaction. Efficient synthesis of an α-amino amide library: Explores the use of T3P in a three-component Ugi reaction, demonstrating its utility in synthesizing a diverse library of α-amino amides (Milen et al., 2017).

  • Cyclization of Linear Tetrapeptides Containing N‐Methylated Amino Acids by using 1‐Propanephosphonic Acid Anhydride: Reports the unexpected findings during the cyclization of linear tetrapeptides, where T3P played a crucial role in enhancing the reaction outcomes (Zhang et al., 2017).


Analysis Note

Assay (T3P) (NMR): ≥ 40.0 %
Pyropropanephosphonic acid (NMR): ≤ 10.0 %
Propanephosphonic acid (NMR): ≤ 0.50 %
2- Methyltetrahydrofurane (calculated): ≤ 50.0 %


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Global Trade Item Number

SKUGTIN
843943002504027269228507
843943005004027269234713
843943010004027269228514