AB1255
Anti-Cytochrome P450 Enzyme CYP1A1 and CYP1A2 Antibody
serum, Chemicon®
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
rat
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable, western blot: suitable
NCBI accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AHRR(57491)
Analysis Note
Control
POSITIVE CONTROL: rat hepatic microsomal fraction.
POSITIVE CONTROL: rat hepatic microsomal fraction.
Application
Detect Cytochrome P450 Enzyme CYP1A1 & CYP1A2 using this Anti-Cytochrome P450 Enzyme CYP1A1 & CYP1A2 Antibody validated for use in ELISA & WB.
Research Category
Metabolism
Metabolism
Research Sub Category
Enzymes & Biochemistry
Enzymes & Biochemistry
Western blot: useful for the simultaneous detection of rat CYP1A1 (57 kDa) and CYP1A2 (54 kDa), which can be separated electrophoretically.
Optimal working dilutions must be determined by end user.
Optimal working dilutions must be determined by end user.
Biochem/physiol Actions
Reacts with rat cytochrome P450 enzyme CYP1A1 and CYP1A2 on Western blots of hepatic microsomal fractions. No cross-reactivity with other cytochrome P450 enzymes.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
Synthetic peptide
Physical form
Rabbit antiserum. Liquid. Contains no preservative.
Preparation Note
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Stephanie E Martinez et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(11), 1314-1324 (2019-08-21)
Dogs are commonly used in human and veterinary pharmaceutical development. Physiologically based pharmacokinetic modeling using recombinant cytochrome P450 (CYP) enzymes requires accurate estimates of CYP abundance, particularly in liver. However, such estimates are currently available for only seven CYPs, which
A role of Wnt/beta-catenin signals in hepatic fate specification of human umbilical cord blood-derived mesenchymal stem cells.
Yoshida, Y; Shimomura, T; Sakabe, T; Ishii, K; Gonda, K; Matsuoka, S; Watanabe, Y; Takubo et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology null
Stephanie E Martinez et al.
Scientific reports, 10(1), 69-69 (2020-01-11)
Greyhounds recover more slowly from certain injectable anesthetics than other dog breeds. Previous studies implicate cytochrome P450 (CYP) 2B11 as an important clearance mechanism for these drugs and suggest Greyhounds are deficient in CYP2B11. However, no CYP2B11 gene mutations have
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