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Merck
CN

AB1891

Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, extracellular loop

Chemicon®, from rabbit

Synonym(s):

CX3CR1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
western blot
Species reactivity:
human
Citations:
9
Technique(s):
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
P49238

Key Documents

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Product Name

Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, extracellular loop, Chemicon®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NM_001337.3

UniProt accession no.

P49238

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CX3CR1(1524)

Application

Anti-C-X-X-X-C Chemokine Receptor 1 Antibody, extracellular loop is an antibody against C-X-X-X-C Chemokine Receptor 1 for use in IH & WB.
Western blot: 1:500 (THP cell lysate can be used as positive control and an approximately 50 kDa band can be detected)

Immunohistochemistry in frozen sections

Optimal working dilutions must be determined by end user.

General description

CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively (1-4). The seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 (5). Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by facktokine (6). CX3CR1 mediates leukocyte migration and adhesion.

Immunogen

Synthetic peptide from the extracellular loop of human CX3CR1.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yuji Kajiwara et al.
Journal of immunology (Baltimore, Md. : 1950), 193(1), 335-343 (2014-06-01)
Response to endotoxins is an important part of the organismal reaction to Gram-negative bacteria and plays a critical role in sepsis and septic shock, as well as other conditions such as metabolic endotoxemia. Humans are generally more sensitive to endotoxins

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