Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb-alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock.

~69 kDa

Cat. # AB2204 will recognize the C-terminus of BMAL1.

Reactivity with other species has not been tested.

Epitope: C-Terminus

Recombinant Protein

Anti-BMAL1 Antibody is an antibody against BMAL1 for use in WB.

Research Category
Neuroscience

Research Sub Category
Circadian Rhythm & Sleep

Serum with 0.05% NaN3

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.

Control
C2C12 Tissue lysate

Routinely tested on C2C12 tissue lysate
Lot Specific Tested Application 1: Western Blot

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.