AB3530P
Anti-Epithelial Sodium Channel-α Antibody
Chemicon®, from rabbit
Synonym(s):
ENaC-alpha
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Product Name
Anti-Epithelial Sodium Channel-α Antibody, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SCNN1A(6337)
Analysis Note
Control
Epithelial structures
Epithelial structures
Application
Anti-Epithelial Sodium Channel-α Antibody is an antibody against Epithelial Sodium Channel-α for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Ion Channels & Transporters
Neuroinflammation & Pain
Ion Channels & Transporters
Neuroinflammation & Pain
Western blot: 1-10 μg/mL using ECL and rat brain membrane preparations, see membrane preparation protocol under Technical Support\General Technical Info\General Methods at www.chemicon.com.
83-90kDa band is expected.
Optimal working dilutions must be determined by the end user.
83-90kDa band is expected.
Optimal working dilutions must be determined by the end user.
Biochem/physiol Actions
Recognizes rat Epithelial Sodium Channel alpha (ENaC alpha). The immunogen shows no significant sequence homology with other ENaC subunits.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
83-90kDa
Immunogen
A 20 amino acid peptide sequence near the N-terminus of rat ENaC alpha (Linguela et al. 1993; Canessa et al.
1993; Snyder et al. 1994; Waldmann et al. 1995; Kreutz et al. 1997; Voilley et al.
1994; McDonald et al. 1994; Ludwig et al. 1998; Garty & Palmer 1997).
1993; Snyder et al. 1994; Waldmann et al. 1995; Kreutz et al. 1997; Voilley et al.
1994; McDonald et al. 1994; Ludwig et al. 1998; Garty & Palmer 1997).
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Affinity Purified immunoglobulin. Liquid in phosphate buffered saline, pH 7.4, containing 0.1% BSA and 0.1% sodium azide.
ImmunoAffinity Purified
Preparation Note
Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Gaizun Hu et al.
American journal of hypertension, 36(9), 509-516 (2023-05-12)
Our previous studies showed that renal medullary sphingosine-1-phosphate receptor 1 (S1PR1) mediated sodium excretion, high salt intake increased S1PR1 level, deoxycorticosterone acetate (DOCA) blocked high salt-induced S1PR1 in the renal medulla, and that conditional knockout of S1PR1 in the collecting
Estrogen increases ENaC activity via PKC? signaling in renal cortical collecting duct cells.
Yusef, YR; Thomas, W; Harvey, BJ
Physiological Reports null
Noriatsu Shigemura et al.
Nutrients, 11(9) (2019-09-25)
The systemic renin-angiotensin system (RAS) is an important regulator of body fluid and sodium homeostasis. Angiotensin II (AngII) is a key active product of the RAS. We previously revealed that circulating AngII suppresses amiloride-sensitive salt taste responses and enhances the
Andreas Ringman Uggla et al.
Neonatology, 99(1), 14-22 (2010-07-01)
It has been suggested from several animal studies and clinical observations that congenital diaphragmatic hernia (CDH) with pulmonary hypoplasia is accompanied by a disturbed perinatal ion transport. This could lead to respiratory distress due to slower clearance of fetal lung
Eman Y Gohar et al.
Journal of the American Heart Association, 11(5), e020450-e020450 (2022-02-23)
Background Premenopausal women are less likely to develop hypertension and salt-related complications than are men, yet the impact of sex on mechanisms regulating Na+ homeostasis during dietary salt challenges is poorly defined. Here, we determined whether female rats have a
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