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AB5459

Sigma-Aldrich

Anti-GABA A Receptor α4 Antibody, CT

Chemicon®, from rabbit

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eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat, mouse, human

manufacturer/tradename

Chemicon®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NM_000809.2

UniProt accession no.

P48169

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... GABRA4(2557)

Specificity

GABA A receptor alpha4 subunit. The apparent molecular mass of the alpha 4 subunit in rat brain membrane fractions is 64 kDa.

Immunogen

Epitope: C-terminus
MBP fusion protein from the cytosolic loop of rat GABA A receptor alpha4 subunit.

Application

Anti-GABA A Receptor α4 Antibody, C-terminus is an antibody against GABA A Receptor α4 for use in IP & WB.
Research Category
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Western blot: 1:1,000

Immunopreciptation: The antibody will immunoprecipitate 8% of all GABA A receptors in sodium dodecyl sulfate extracts of rat forebrains (150 μL) using 20 μg of antibody.

Optimal working dilutions must be determined by the end user.

Physical form

Affinity purified immunoglobulin in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.

Storage and Stability

Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Certificates of Analysis (COA)

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25G
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Neus Pedraza et al.
Cellular and molecular life sciences : CMLS, 80(10), 280-280 (2023-09-09)
Nuclear Cyclin D1 (Ccnd1) is a main regulator of cell cycle progression and cell proliferation. Interestingly, Ccnd1 moves to the cytoplasm at the onset of differentiation in neuronal precursors. However, cytoplasmic functions and targets of Ccnd1 in post-mitotic neurons are
S Hossein Fatemi et al.
Journal of autism and developmental disorders, 40(6), 743-750 (2010-01-13)
We have shown altered expression of gamma-aminobutyric acid A (GABA(A)) and gamma-aminobutyric acid B (GABA(B)) receptors in the brains of subjects with autism. In the current study, we sought to verify our western blotting data for GABBR1 via qRT-PCR and
S Hossein Fatemi et al.
Synapse (New York, N.Y.), 71(7) (2017-03-21)
Schizophrenia and bipolar disorder are complex psychiatric disorders that affect millions of people worldwide. Evidence from gene association and postmortem studies has identified abnormalities of the gamma-aminobutyric acid (GABA) signaling system in both disorders. Abnormal GABAergic signaling and transmission could

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