AB5511
Anti-Opioid Receptor Antibody, µ, pain
serum, Chemicon®
Synonym(s):
mu opiate receptor, opioid receptor, mu 1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
mouse, primate, rat, human
Citations:
26
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
Product Name
Anti-Opioid Receptor Antibody, µ, pain, serum, Chemicon®
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, primate, rat, human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... OPRM1(4988)
Analysis Note
Control
Spinal cord, liver lysate
Spinal cord, liver lysate
Evaluated by Western Blot on Human Liver lysate.
Western Blot Analysis:
1:500 dilution of this antibody detected Opioid Receptor on 10 µg of Human Liver lysate.
Western Blot Analysis:
1:500 dilution of this antibody detected Opioid Receptor on 10 µg of Human Liver lysate.
Application
Detect Opioid Receptor using this Anti-Opioid Receptor Antibody, µ, pain validated for use in IC, IH & WB.
Immunohistochemistry:
1:2,500-1:5,000 dilution of a previous lot was used.
Western blot:
1:1,000 dilution of a previous lot was used.
Immunocytochemistry:
1:2,500-1:5,000 dilution of a previous lot was used.
Optimal working dilutions must be determined by the end user.
1:2,500-1:5,000 dilution of a previous lot was used.
Western blot:
1:1,000 dilution of a previous lot was used.
Immunocytochemistry:
1:2,500-1:5,000 dilution of a previous lot was used.
Optimal working dilutions must be determined by the end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neuroinflammation & Pain
Neuroinflammation & Pain
Biochem/physiol Actions
Mu Opioid receptor.
Other species have not been tested.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
45 kDa
Opiates derived from the opium poppy, Papaver somniferum, have been used for millenia for their anti-diarrheal, analgesic and euphoric properties. More recently, endogenous peptides, enkephalins, dynorphins, and endorphins, were found to bind to the same sites as opiate alkaloids. The receptors for the classical opioids are three related GPCRs, δ, κ, and µ (also known as OP1, OP2 and OP3, respectively), that activate Gi/o to reduce intracellular cAMP levels. Although most clinically used opioids function by activation of the µ opioid receptor, agonists of spinal δ opioid receptors have antinociceptive activity that is independent of µ. In addition, activation of δ increases locomotor activity, inhibits gastrointestinal motility, and decreases respiratory frequency (Dhawan et al., 1996). Agonists for δ opioid receptors also exhibit antidepressant-like activity in animal models (Broom et al., 2002).
Immunogen
Epitope: C-terminus
Synthetic peptide from the C-terminus of rat Mu Opioid receptor.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Physical form
Rabbit polyclonal serum in buffer containing 0.05% sodium azide.
Unpurified
Preparation Note
Stable for 1 year at -20ºC from date of receipt.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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S Pain et al.
International journal of cosmetic science, 32(4), 266-275 (2010-04-14)
Much effort has been placed in cosmetic research for better understanding of the effects of ageing on skin's appearance, structure, mechanical properties and function. It is now of common knowledge that UV radiations induce pre-mature skin ageing notably in the
MOP Reduction During Long-Term Methamphetamine Withdrawal was Restored by Chronic Post-Treatment with Fluoxetine.
Yamamoto H, Takamatsu Y, Imai K, Kamegaya E, Hagino Y, Watanabe M, Yamamoto T, Sora I et al.
Current Neuropharmacology null
Differential regulation of morphine antinociceptive effects by endogenous enkephalinergic system in the forebrain of mice.
Chen, TC; Cheng, YY; Sun, WZ; Shyu, BC
Molecular Pain null
Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: a potential compensatory role.
Koizumi, H; Morigaki, R; Okita, S; Nagahiro, S; Kaji, R; Nakagawa, M; Goto, S
Frontiers in Cellular Neuroscience null
Jing Li et al.
Alcoholism, clinical and experimental research, 41(3), 637-643 (2017-02-07)
Hyperalgesia or increased sensitivity to pain is often found in alcoholics during alcohol withdrawal and may contribute to relapse drinking. Alternative therapies such as acupuncture and electroacupuncture (EA), through mechanisms involving opioid receptors, may reduce pain and substance dependence and
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