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Merck
CN

AB5652P

Anti-Histamine Receptor 1 Antibody, CT

Chemicon®, from rabbit

Synonym(s):

H1R

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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Product Name

Anti-Histamine Receptor 1 Antibody, CT, Chemicon®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

bovine, mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

ELISA: suitable
western blot: suitable

NCBI accession no.

NM_000861.3
NM_001098211.1
NM_001098212.1
NM_001098213.1

UniProt accession no.

P35367

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

mouse ... Hrh1(15465)
rat ... Hrh1(24448)

Application

Research Category
Inflammation & Immunology
Research Sub Category
Inflammation & Autoimmune Mechanisms
This Anti-Histamine Receptor 1 Antibody, C-terminus is validated for use in ELISA, WB for the detection of Histamine Receptor 1.
Western blot: 1-10 μg/mL using ECL. Recognizes a 57kDa band representing the H1 receptor

ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well.

Optimal working dilutions must be determined by the end user.

Biochem/physiol Actions

Recognizes rat Histamine Receptor 1 (HR1). The immunogen shows no significant sequence homology with other histamine receptors.

The immunogen peptide is 100% conserved in mouse and bovine, 94% in human, fish and monkey and 80% in guinea pig. Reactivity with other species has not been confirmed.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

A 17 amino acid peptide sequence near the cytoplasmic, C-terminus of rat HR1 (Fujimoto et al. 1993; Inoue et al. 1996; DeBacker et al. 1993; Fukui et al. 1994; Moguilevsky et al. 1994).
Epitope: C-terminus

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA.

Preparation Note

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hiroshi Azuma et al.
The Laryngoscope, 114(12), 2249-2251 (2004-11-27)
Histamine may have physiologic functions in the inner ear. The locations of histamine receptors, however, have not yet been identified in the mammalian cochlea. The aim of this study was to investigate the localization of histamine receptor subtypes (H1, H2
Matthew J Gastinger et al.
The Journal of comparative neurology, 495(6), 658-667 (2006-03-01)
Mammalian retinas are innervated by histaminergic axons that originate from perikarya in the posterior hypothalamus. To identify the targets of these retinopetal axons, we localized histamine receptors (HR) in monkey and rat retinas by light and electron microscopy. In monkeys
Kathryn M Lenz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(37), 8044-8059 (2018-08-11)
Many sex differences in brain and behavior are programmed during development by gonadal hormones, but the cellular mechanisms are incompletely understood. We found that immune-system-derived mast cells are a primary target for the masculinizing hormone estradiol and that mast cells

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