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ABC504

Sigma-Aldrich

Anti-IGF2 Antibody

from rabbit, purified by affinity chromatography

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Synonym(s):
Insulin-like growth factor 2, IGF-2, Somatomedin-A, Insulin-like growth factor 2, Insulin-like growth factor 2 Ala-25 Del, Preptin
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

technique(s)

western blot: suitable

NCBI accession no.

NP_000603

UniProt accession no.

P01344

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... IGF2(3481)

General description

Human Insulin-like Growth Factor 2 (IGF2) contains 67 amino acids and shares similar structural features with IGF1, including a 62% sequence homology. In human plasma, IGF1 and IGF2 are associated with IGF-binding proteins that transport the polypeptides and partially regulate their actions in vivo. In addition to the insulin receptor, IGF2 binds to two forms of IGF receptors, both of which are widely distributed in different tissues and cultured cells. IGF2 is mitogenic for a variety of cultured cells, including mouse 3T3 cells,12 normal rat kidney cells, human or chicken fibroblasts and MCF-7 human breast carcinoma cells.

Immunogen

Epitope: Insulin-like growth factor 2 mature chain
KLH-conjugated linear peptide corresponding to the human Insulin-like growth factor 2 mature chain.

Application

Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
This Anti-IGF2 Antibody is validated for use in Western Blotting for the detection of IGF2.

Quality

Evaluated by Western Blotting in human placenta tissue lysate.

Western Blotting Analysis: A 1:500 dilution of this antibody detected IGF2 in 10 µg of human placenta tissue lysate.

Target description

~24 kDa observed. This antibody detects all 3 isoforms of IGF2 (20-26 kDa), and may run higher than expected due to glycosylation.

Physical form

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Dandan Wang et al.
PLoS genetics, 17(10), e1009862-e1009862 (2021-10-29)
ZBED6 (zinc finger BED domain containing protein 6) is a transcription factor unique to placental mammals and its interaction with the IGF2 (insulin-like growth factor 2) locus plays a prominent role in the regulation of postnatal skeletal muscle growth. Here
Denise Rockstroh et al.
European journal of endocrinology, 180(1), K1-K13 (2018-11-08)
Objective The IGF/IGF1R axis is involved in the regulation of human growth. Both IGF1 and IGF2 can bind to the IGF1R in order to promote growth via the downstream PI3K/AKT pathway. Pathogenic mutations in IGF1 and IGF1R determine intrauterine growth
Yanbin Zheng et al.
Molecular cancer research : MCR, 18(3), 364-374 (2019-11-24)
We recently developed a novel computational algorithm that incorporates Bayesian methodology to identify rhabdomyosarcoma disease genes whose expression level correlates with copy-number variations, and we identified PLAG1 as a candidate oncogenic driver. Although PLAG1 has been shown to contribute to

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