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Key Documents

ABC95

Sigma-Aldrich

Anti-Praf2 (JM4) Antibody

serum, from rabbit

Synonym(s):

PRA1 family protein 2, Prenylated Rab acceptor 1 family protein 2, PRAF2, JM4

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, rat

species reactivity (predicted by homology)

bovine (based on 100% sequence homology), dog (based on 100% sequence homology), hamster (based on 100% sequence homology), guinea pig (based on 100% sequence homology), horse (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_009144

UniProt accession no.

O60831

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... PRAF2(11230)

General description

Prenylated Rab acceptor 1 family protein 2 (PRAF2), or JM4, is a novel 19-kDa transmembrane protein belonging to the PRA1 family. It is highly expressed in the brain, and has been shown to be enriched in synaptic vesicles. PRAF2 is also relatively abundant in the spleen, small intestine, lung, pancreas, as well as various tumors affecting the ovary, breast, and colon. Recent studies have identified PRAF2 as a potential marker for neuroblastoma. Like other PRAF1 proteins, it is localized to the golgi, endoplasmic reticulum, and vesicular structures. The precise role of PRAF2 is not yet clear, but studies suggest that it may play a role in cellular transport processes.

Immunogen

KLH-conjugated linear peptide corresponding to human Praf2 (JM4).

Application

Anti-Praf2 (JM4) Antibody is an antibody against Praf2 (JM4) for use in Western Blotting & IHC.
Immunohistochemistry Analysis: A representative lot detected Praf2 (JM4) in mouse and human cerebellum tissue and in human breast cancer tissue.
Research Category
Apoptosis & Cancer

Neuroscience
Research Sub Category
Apoptosis - Additional

Synapse & Synaptic Biology

Quality

Western Blot Analysis: A 1:2,000 dilution from a representative lot detected Praf2 (JM4) in 10 µg of SK-N-SH cell lysate.

Target description

~18 kDa observed

Physical form

Rabbit polyclonal serum containing with 0.05% sodium azide.
Unpurified

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Analysis Note

Control
SK-N-SH cell lysate

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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