NAD-dependent protein deacetylase sirtuin-4 (SIRT4) is also called NAD-dependent ADP-ribosyltransferase sirtuin-4 and SIR2-like protein 4 (SIR2L4). SIRT4 catalyzes the transfer of ADP-ribosyl groups onto target proteins, and has been shown to inhibit GLUD1 enzyme activity, down-regulate insulin secretion and is involved in chromatin silencing. SIRT4 is believed to be a transcriptional regulator in embyonic stem cell and hematopoietic stem cells. SIRT4 is widely expressed and has been detected in vascular smooth muscle and striated muscle, and pancreatic (islets of Langerhans) insulin-producing beta-cells.

This antibody is predicted to not cross-react with other Sirtuin family members.

Epitope: N-terminus

KLH-conjugated synthetic peptide corresponding to the N-terminus of human SIRT4.

Anti-SIRT4 Antibody detects level of SIRT4 & has been published & validated for use in SIRT4.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Cell Cycle, DNA Replication & Repair

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 1 μg/mL of this antibody detected SIRT4 in human liver tissue lysate.

~38 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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