Bone marrow stromal cell antigen 2 (BST-2, Bst2), also known as CD317, and HM1.24 antigen, is an IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian viruses by directly tethering nascent virions to the membranes of infected cells. Bst2 has been shown to interact with various viruses, including: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Bst2 may inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Additionally, it is implied to interact with LILRA4/ILT7, which results in providing negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. This activity suggests that Bst2 can provide a potential therapeutic strategy for the treatment of HIV/AIDS. Bst2 may play a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells

This antibody recognizes the N-terminus of Bst2.

Epitope: N-terminus

KLH-conjugated linear peptide corresponding to the N-terminus of mouse Bst2.

Detect Bone marrow stromal antigen 2 using this rabbit polyclonal antibody, Anti-Bst2 Antibody validated for use in western blotting.

Research Category
Inflammation & Immunology

Research Sub Category
Immunological Signaling

Western Blotting Analysis: 2 µg/mL from a representative lot detected Bst2 in 15 µg of Daudi cell lysate.

Evaluated by Immunohistochemistry in human placenta tissue.

Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Bst2 in human placenta tissue.

~22 kDa observed. Uncharacterized bands may appear in some lysate(s).

Replaces: MABF201

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Human placenta tissue

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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