ABF206
Anti-TRIM5 alpha Antibody
from rabbit, purified by affinity chromatography
Synonym(s):
Tripartite motif-containing protein 5, RING finger protein 88
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC, WB
Citations:
1
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, western blot: suitable
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... TRIM5(85363)
General description
Tripartite motif-containing protein 5 (TRIM5), also known as RING finger protein 88 (RNF88), is a member of the TRIM/RBCC family defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the alpha variant which also contains a carboxy-terminal B30.2 (SPRY) domain. TRIM5 isoform alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection.
~55 kDa observed. Uniprot describes 6 isoforms ranging between ~30 kDa and ~56 kDa Uncharacterized bands may appear in some lysates.
Immunogen
KLH-conjugated linear peptide corresponding to the intermediate domain of human TRIM5 alpha.
Application
Detect Tripartite motif-containing protein 5 using this rabbit polyclonal antibody, Anti-TRIM5 alpha Antibody validated for use in western blotting, IHC & Immunofluorescence.
Immunohistochemistry Analysis: 2 µg/mL from a representative lot detected TRIM5 alpha in human stomach tissue.
Immunofluorescence Analysis: 10 µg/mL from a representative lot detected TRIM5 alpha in human stomach cells.
Immunofluorescence Analysis: 10 µg/mL from a representative lot detected TRIM5 alpha in human stomach cells.
Biochem/physiol Actions
This antibody recognizes the intermediate domain of TRIM5 alpha.
Analysis Note
Control
Human stomach, thymus, and uterus tissue lysates
Human stomach, thymus, and uterus tissue lysates
Evaluated by Western Blotting in human stomach, thymus, and uterus tissue lysates.
Western Blotting Analysis: 2 µg/mL of this antibody detected TRIM5 alpha in 15 µg of human stomach, thymus, and uterus tissue lysates.
Western Blotting Analysis: 2 µg/mL of this antibody detected TRIM5 alpha in 15 µg of human stomach, thymus, and uterus tissue lysates.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Related Content
Venkata Subba Rao Atluri et al.
Scientific reports, 6, 27864-27864 (2016-06-21)
We have observed significantly increased HIV infection in HIV infected macrophages in the presence of cocaine that could be due to the downregulation of BST2 restriction factor in these cells. In human inflammasome PCR array, among different involved in inflammasome
Global Trade Item Number
| SKU | GTIN |
|---|---|
| ABF206 | 04053252910555 |