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ABN485

Anti-SIPA1L1 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

Signal-induced proliferation associated-like protein 1, SIPA1-like protein 1, E6TP1, High-risk human papilloma viruses E6 oncoproteins targeted protein 1, E6-targeted protein 1, SIPA1L1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
1
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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, rat

technique(s)

immunohistochemistry: suitable, western blot: suitable

UniProt accession no.

O43166

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... SIPA1L1(26037)

General description

Signal-induced proliferation associated-like protein 1 (SIPA1L1), also called High-risk human papilloma viruses E6 oncoproteins targeted protein 1 (E6-targeted protein 1) is widely expressed and bound at the carboxy-terminus by Casein kinase I epsilon (CKIe) which leads to phosphorylation. SIPA1L1 activates RAP2A GTPase activity, aids reorganization of the actin cytoskeleton, recruits DLG4 to F-actin, regulates dendritic spine morphogenesis, and plays important roles in embryo development and cell proliferation.
~200 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 2 isoforms at ~198 kDa and ~200 kDa

Immunogen

KLH-conjugated linear peptide corresponding to human SIPA1L1.

Application

Anti-SIPA1L1 Antibody is a highly specific rabbit polyclonal antibody, that targets Signal-induced proliferation associated-like protein 1 & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected SIPA1L1 in human brain tissue.

Analysis Note

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected SIPA1L1 in 15µg of rat brain tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Qi Ma et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(41), E8760-E8769 (2017-10-05)
Ubiquitination-directed proteasomal degradation of synaptic proteins, presumably mediated by lysine 48 (K48) of ubiquitin, is a key mechanism in synapse and neural circuit remodeling. However, more than half of polyubiquitin (polyUb) species in the mammalian brain are estimated to be

Global Trade Item Number

SKUGTIN
ABN48504053252905520