Junctophilin-3 (JPH3, JP-3), also known as Trinucleotide repeat-containing gene 22 protein (TNRC22), is a single-pass type IV membrane protein belonging to the junctophilin family. Junctophilins are important components of the junctional complexes which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. JPH3 is specifically expressed in brain. A mutation associated with JPH3 is the cause of Huntington disease-like type 2 (HDL2), a neurodegenerative disorder.

This antibody recognizes the C-terminus of JPH3.

Epitope: Near C-terminus.

KLH-conjugated linear peptide corresponding to a sequence near the C-terminus of human JPH3.

Anti-JPH3 Antibody is a highly specific rabbit polyclonal antibody, that targets Junctophilin-3 & has been tested in western blotting, IHC & Immunofluorescence.

Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected JPH3 in human brain tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected JPH3 in human brain cells.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Evaluated by Western Blotting/Peptide Inhibition Assay in Daudi cell lysate.

Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected JPH3 in 15 µg of Daudi cell lysate.

~105 kDa observed. Uniprot describes 2 isoforms at ~20 kDa and ~81 kDa Uncharacterized bands may appear in some lysates.

Affinity purified.

Purified rabbit polyclonal antibody in buffer containing PBS with 0.02% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
Daudi cell lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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