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Merck
CN

ABS102

Anti-AKAP 79 Antibody

from rabbit, purified by affinity chromatography

Synonym(s):

A-kinase anchor protein 5, AKAP-5, A-kinase anchor protein 79 kDa, AKAP 79, H21, cAMP-dependent protein kinase regulatory subunit II high affinity-binding protein

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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Product Name

Anti-AKAP 79 Antibody, from rabbit, purified by affinity chromatography

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

technique(s)

western blot: suitable

NCBI accession no.

NP_004848

UniProt accession no.

P24588

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... AKAP5(9495)

Analysis Note

Control
HEK293 cell lysate with overexpressed N-terminal Flag-AKAP79
Evaluated by Western Blot in HEK293 cell lysate with overexpressed N-terminal Flag-AKAP79.

Western Blot Analysis: 1 µg/mL of this antibody detected AKAP 79 on 10 µg of HEK293 cell lysate with overexpressed N-terminal Flag-AKAP79.

Application

Detect AKAP 79 using this Anti-AKAP 79 Antibody validated for use in WB.

Biochem/physiol Actions

This antibody recognizes AKAP 79 at the C-terminus.

General description

A-kinase anchoring protein 79 (AKAP 79) is a scaffolding protein that resides predominantly in excitatory neuronal synapses. AKAP 79 interacts with membrane-associated guanylate kinase (MAGUK) to be used by glutamate receptors. AKAP 79 may also be involved with SAP97 and other large signaling complexes. AKAP 79 is essential for forskolin-induced up-regulation of L-current.
~79 kDa observed.
AKAP79 migrates in WB with an apparent molecular weight of ~79 kDa Uncharacterized bands appear at ~35 kDa and ~13 kDa in some lysates.

Immunogen

KLH-conjugated linear peptide corresponding to the C-terminus of human AKAP 79.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Kevin M Riggle et al.
Pediatric research, 80(1), 110-118 (2016-03-31)
Fibrolamellar hepatocellular carcinoma (FL-HCC) affects children without underlying liver disease. A consistent mutation in FL-HCCs leads to fusion of the genes encoding a heat shock protein (DNAJB1) and the catalytic subunit of protein kinase A (PRKACA). We sought to characterize
Maria Paz Prada et al.
Nature communications, 11(1), 5303-5303 (2020-10-22)
The L-type Ca2+ channel CaV1.2 is essential for arterial myocyte excitability, gene expression and contraction. Elevations in extracellular glucose (hyperglycemia) potentiate vascular L-type Ca2+ channel via PKA, but the underlying mechanisms are unclear. Here, we find that cAMP synthesis in
Srgjan Civciristov et al.
Science signaling, 11(551) (2018-10-12)
G protein-coupled receptors (GPCRs) are the largest class of cell surface signaling proteins, participate in nearly all physiological processes, and are the targets of 30% of marketed drugs. Typically, nanomolar to micromolar concentrations of ligand are used to activate GPCRs

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