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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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biological source

rabbit

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

species reactivity (predicted by homology)

horse (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

NCBI accession no.

NP_689935

UniProt accession no.

Q14CZ8

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... HEPACAM(220296)

General description

Gene HepaCAM, which is frequently silenced in hepatocellular carcinoma (HCC), encodes an Ig-like transmembrane glycoprotein. This glycoprotein serves as a type of cell adhesion molecule (CAM), which interacts with other CAMs on the adjacent cell surface or with proteins found in the extracellular matrix. It is observed to regulate cellular growth and cell-matrix adhesion. It also plays a role in cellular migration.

Specificity

Other homologies: Mouse, Rat, and Bovine (96% sequence homology).
This antibody recognizes the cytoplasmic domain of HepaCAM-1.

Immunogen

KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human HepaCAM-1.

Application

Detect the HepaCAM-1 protein using this Anti-HepaCAM-1 validated for use in WB & IHC.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected HepaCAM-1 in human liver and human breast carcinoma tissues.

Quality

Evaluated by Western Blot in human liver tissue lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected HepaCAM-1 in 10 µg of human liver tissue lysate.

Target description

~53 kDa observed. Two isoforms at ~40 kDa and ~46 kDa are known to exist. This protein is known to be glycosylated in HT-1080 and HEPG2 cell lysates (Chung, M. M., et al. (2005). J Hepatol. 42(6):833-841.).

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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