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Merck
CN

AP1140

Anti-GBA Mouse mAb (2E2)

liquid, clone 2E2, Calbiochem®

Synonym(s):

Anti-Glucosidase β, Acid

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-GBA Mouse mAb (2E2), liquid, clone 2E2, Calbiochem®

biological source

mouse

antibody form

purified antibody

antibody product type

primary antibodies

clone

2E2, monoclonal

form

liquid

does not contain

preservative

species reactivity

human

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

dilution

(ELISA
Immunoblotting (1-5 µg/mL)
Immunocytochemistry (10 µg/mL)
Paraffin Sections (3 µg/mL))

isotype

IgG2a

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... GBA(2629)

Analysis Note

Negative Control
293T
Positive Control
MCF-7 cells, HeLa cells, Human breast cancer tissue

Application

ELISA Immunoblotting (1-5 µg/mL)Immunocytochemistry (10 µg/mL)Paraffin Sections (3 µg/mL)

Disclaimer

Toxicity: Regulatory Review (Z)

General description

Anti-GBA, mouse monoclonal, clone 2E2, recognizes the ~60 kDa GBA in MCF-7 and HeLa cells and human breast cancer tissue. It is validated for use in ELISA, WB, ICC, and IHC on paraffin sections.
Purified mouse monoclonal antibody. Recognizes the ~60 kDa GBA protein.
Recognizes the ~60 kDa GBA protein in MCF-7 and HeLa cells and human breast cancer tissue.

Immunogen

A recombinant polypeptide corresponding to amino acids of 146-236 human GBA, expressed as a GST fusion protein

Other Notes

Campeau, P.M., et al. 2009. Blood114, 3181.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Laura J Smith et al.
Human molecular genetics, 32(5), 773-789 (2022-09-22)
Sequence variants or mutations in the GBA gene are numerically the most important risk factor for Parkinson disease (PD). The GBA gene encodes for the lysosomal hydrolase enzyme, glucocerebrosidase (GCase). GBA mutations often reduce GCase activity and lead to the
Ruggero Ferrazza et al.
Biochemical and biophysical research communications, 478(3), 1141-1146 (2016-08-20)
Mutations in LRRK2 gene cause inherited Parkinson's disease (PD) and variations around LRRK2 act as risk factor for disease. Similar to sporadic disease, LRRK2-linked cases show late onset and, typically, the presence of proteinaceous inclusions named Lewy bodies (LBs) in

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