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UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.32
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Product Name

Human Total Proinsulin ELISA, This Human Total Proinsulin ELISA is used to measure & quantify Proinsulin levels in Metabolism & Endocrine & Cell Signaling research.

Quality Level

200

species reactivity

human

packaging

kit of 1 × 96 wells

parameter

20 μL sample volume (4hr assay)

assay range

accuracy: 88-103%
linearity: 84-120%
sensitivity: 0.5 pM
standard curve range: 2-200 pM

technique(s)

ELISA: suitable

input

sample type serum
sample type plasma (K2 EDTA)

NCBI accession no.

NM_000207.2

UniProt accession no.

P01308

application(s)

research use

detection method

colorimetric (450nm)

shipped in

wet ice

storage temp.

2-8°C

General description

Proinsulin, the precursor of insulin and C-peptide, is made by the β cells of the pancreas. Proinsulin formed by the cleavage of pre-proinsulin contains B- and A-domains linked through the connecting domain. Proinsulin interacts with insulin receptor-A (IR-A) isoform present in the nervous system and exhibits antiapoptotic and neuroprotective effects in the developing and postnatal nervous system. Elevated levels of proinsulin serve as a marker for secretory β-cell dysfunction. Increased levels of this hormone are also observed in patients with type 2 diabetes and impaired glucose tolerance. This kit measures the intact and intermediate metabolic forms of human proinsulin.

Application

Human Total Proinsulin ELISA has been used to measure plasma, serum, eye, and retinal levels of human proinsulin.

Other Notes

Research Sub Category
Obesity
Metabolic Disorders
Research Category
Metabolism
20 μL sample volume 3 hour assay, room temperature

Disclaimer

For research use only. Not for use in diagnostic procedures.

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Warning

Hazard Statements

H290,H317

Hazard Classifications

Met. Corr. 1 - Skin Sens. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

Certificates of Analysis (COA)

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