Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the ′beads on a string′ structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.

17 kDa observed

Broad species cross-reactivity is expected.

Histone H3 phosphorylated at Ser10

A proprietary immunogen based on a peptide sequence containing phospho-serine corresponding to residue 10 of human histone H3.

Epitope: Ser10

Anti-Phospho-Histone H3 (Ser10) Antibody, clone 3H10, Alexa Fluor^™ 488, is a Mouse Monoclonal Antibody for detection of Histone H3 phosphorylated at serine 10. This purified mAb, also known as H3S10p,
is labeled with Alexa Fluor 488 and validated for use in FC.

Research Category
Epigenetics & Nuclear Function

Apoptosis & Cancer

Research Sub Category
Histones

Cell Cycle, DNA Replication & Repair

Protein G Purified

Purified mouse IgG1k conjugated to Alexa Fluor^™ 488 in PBS with 15mg/mL BSA and less than 0.09% sodium azide.

Maintain refrigerated at 2-8oC in undiluted aliquots for up to 6 months from date of receipt. Protect from light.

Control
Jurkat Cells

Evaluated by Flow Cytometry with Jurkat cells.

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