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GF309

NT-4 Protein, Human Recombinant Animal Free

Name: NT-4 Protein, Human Recombinant Animal Free
Brand: MM

The Neurotrophin-4 protein (or NT-4 protein), also known as NT-5 protein, is a member of the NGF family of neuronal & epithelial growth factors.

Synonym(s):

NT4, Neurotrophin 4, Neurotrophin 4/5, NT4/5

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.77

eCl@ss:

32160405

Assay:

>98% (SDS-PAGE and HPLC)

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Properties

Quality Segment

100

assay

>98% (SDS-PAGE and HPLC)

impurities

<0.1 μg/mg protein endotoxin (<1EU/μg)

NCBI accession no.

NM_006179.3

UniProt accession no.

P34130

shipped in

dry ice

storage temp.

-10 to -25°C

Description

General description

Neurotrophin4 (NT4), also known as NT5, is a member of the NGF family of neuronal and epithelial growth factors. NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-4 is expressed in the prostate, thymus, placenta and skeletal muscle. NT-4 can signal through the LNGFR and trkB receptors and promotes the survival of peripheral sensory sympathetic neurons. Recombinant human NT-4 is a noncovalently linked homodimer, of two 14.0 kDa polypeptide monomers (260 total amino acid residues).

Biochem/physiol Actions

Cross Reactivty
Mouse, Rat

Physical form

Recombinant animal free human NT-4 is manufactured using all non-animal reagents

Analysis Note

Bioactivity assay: The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found in the range of 20-50 ng/ml.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c