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HBNMAG-51K

MILLIPLEX® Human Bone Panel

Configurable Human Bone 13-Plex Panel

Synonym(s):

human bone metabolic biomarkers immunoassay panel, luminex human bone metabolism multiplex assay, millipore human bone metabolic biomarkers multiplex kit, bone turnover assay overview, human bone biomarker panel, human bone metabolism assay, inflammation and bone health panel, skeletal disease multiplex kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Key Documents

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Product Name

MILLIPLEX® Human Bone Panel,

species reactivity

human

Quality Level

200

description

Configurable Human Bone 13-Plex Panel

assay range

accuracy: 82-97%, standard curve range: 0.24-1,000 pg/mL
(TNFα), standard curve range: 1-3,000 pg/mL
(IL-1β), standard curve range: 1-6,000 pg/mL
(ACTH & IL-6), standard curve range: 146-600,000 pg/mL
(OC), standard curve range: 24-100,000 pg/mL
(SOST), standard curve range: 37-150,000 pg/mL
(FGF-23), standard curve range: 49-200,000 pg/mL
(Leptin), standard curve range: 5-20,000 pg/mL
(DKK-1), standard curve range: 5-20,000 pg/mL
(PTH), standard curve range: 61-250,000 pg/mL
(Insulin), standard curve range: 7-30,000 pg/mL
(OPG), standard curve range: 98-400,000 pg/mL
(OPN)

technique(s)

multiplexing: suitable

input

serum plasma (cell culture supernatants, tissue/cell extracts)

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

General description

Bone health is regulated by a complex interplay of hormonal, inflammatory, and metabolic signals. This panel—ACTH, DKK1, FGF-23, IL-1β, IL-6, Insulin, Leptin, Osteocalcin (OC), Osteopontin (OPN), Osteoprotegerin (OPG), PTH, Sclerostin (SOST), and TNFα—captures key indicators of bone remodeling, endocrine function, and immune activity. These analytes are valuable for studying osteoporosis, arthritis, and metabolic bone diseases, supporting both translational and clinical research in skeletal biology.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 13 analytes in human serum, plasma, or cell/tissue culture supernatants.

Analytes Included: ACTH, DKK1, FGF-23, IL-1β, IL-6, Insulin, Leptin, Osteocalcin (OC), Osteopontin (OPN), Osteoprotegerin (OPG), PTH, Sclerostin (SOST), TNFα

Assay Characteristics: Refer to assay protocol for details on cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

Features:
  • Targets biomarkers involved in bone remodeling, endocrine regulation, and inflammation
  • Includes 13 analytes relevant to skeletal health, metabolic activity, and immune signaling
  • Multiplex format enables simultaneous detection from minimal sample volume
  • Compatible with human serum, plasma, and cell/tissue culture supernatants
  • Designed for research in osteoporosis, arthritis, endocrine disorders, and bone metabolism
Benefits:
  • Provides a comprehensive profile of bone turnover and inflammatory biomarkers
  • Supports investigation of skeletal disease mechanisms and endocrine regulation
  • Facilitates evaluation of therapeutic interventions and disease progression
  • Enables high-throughput analysis with reduced sample and reagent use
  • Delivers reproducible, sensitive results for translational and clinical research

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Regulatory Information

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Chiara Giannasi et al.
International journal of medical sciences, 16(1), 23-32 (2019-01-22)
Bisphosphonates (BPs) represent the first-line treatment for a wide array of bone disorders. Despite their well-known action on osteoclasts, the effects they induce on osteoblasts are still unclear. In order to shed light on this aspect we evaluated the impact
Fawaz Y Azizieh et al.
Biomarker insights, 14, 1177271919843825-1177271919843825 (2019-08-28)
Receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), and oxidative stress markers are suggested to contribute to bone loss in osteoporosis that occurs in menopause. However, the association between these markers and bone mineral density (BMD) is controversial.
Ravit Regev et al.
Bone reports, 14, 100747-100747 (2021-01-29)
MCTO is a rare disorder, caused by mutations in the MafB gene, a negative regulator of receptor activator of nuclear factor-кB ligand (RANKL). Manifestations include carpal and tarsal osteolysis and renal failure. Pathophysiology is poorly understood, and no effective treatment
Javier Diaz-Castro et al.
Food & function, 11(9), 7523-7531 (2020-08-17)
Bone and energy metabolism are profoundly influenced by exercise. The objective of this study was to determine for the first time whether a short-term supplementation with ubiquinol could have a modulating effect on bone turnover and energy metabolism associated with
Stephen M Ford et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 311(5), R888-R897 (2016-11-03)
Alcohol use disorders (AUDs) frequently exist among persons living with HIV/AIDS. Chronic alcohol consumption, HIV infection, and antiretroviral therapy (ART) are independently associated with impairments in glucose-insulin dynamics. Previous studies from our laboratory have shown that chronic binge alcohol (CBA)
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