HBNMAG-51K

MILLIPLEX^® 人骨磁珠板 - 骨代谢多重检测

Name: MILLIPLEX<SUP>®</SUP> 人骨磁珠板 - 骨代谢多重检测
Brand: MM

The analytes available for this multiplex kit are: ACTH, DKK-1, FGF-23, IL-1β, IL-6, Insulin, Leptin, Osteocalcin, OPN - Osteopontin, Osteoprotegerin, PTH, SOST, TNF-α.

别名:

human bone metabolic biomarkers immunoassay panel, luminex human bone metabolism multiplex assay, millipore human bone metabolic biomarkers multiplex kit

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关于此项目

UNSPSC代码:

12161503

eCl@ss:

32161000

NACRES:

NA.84

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质量水平

200

种属反应性

human

制造商/商品名称

Milliplex^®

assay range

accuracy: 82-97%
standard curve range: 0.24-1,000 pg/mL
(TNFα)
standard curve range: 1-3,000 pg/mL
(IL-1β)
standard curve range: 1-6,000 pg/mL
(ACTH & IL-6)
standard curve range: 146-600,000 pg/mL
(OC)
standard curve range: 24-100,000 pg/mL
(SOST)
standard curve range: 37-150,000 pg/mL
(FGF-23)
standard curve range: 49-200,000 pg/mL
(Leptin)
standard curve range: 5-20,000 pg/mL
(DKK-1)
standard curve range: 5-20,000 pg/mL
(PTH)
standard curve range: 61-250,000 pg/mL
(Insulin)
standard curve range: 7-30,000 pg/mL
(OPG)
standard curve range: 98-400,000 pg/mL
(OPN)

技术

multiplexing: suitable

检测方法

fluorometric (Luminex xMAP)

运输

wet ice

一般描述

骨代谢是由成骨细胞，骨细胞和破骨细胞控制的正在进行的骨沉积和吸收的动态过程。而成骨细胞和骨细胞（被基质包围的成骨细胞）负责骨沉积，而破骨细胞则负责骨吸收。两者都需要维持骨骼结构以及充足的钙供应。为了维持这种代谢平衡，这些细胞依赖于涉及激素和细胞因子的复杂信号传导途径来实现适当的生长和分化速率。骨代谢紊乱可导致骨质疏松症、骨关节炎、类风湿关节炎、慢性肾脏疾病和骨转移等疾病。

MILLIPLEX^®人骨磁珠试剂盒用于同时定量人血浆、血清或组织/细胞裂解物和培养上清液样品中以下分析物的任何或全部：促肾上腺皮质激素（ACTH)，Dickkopf-1（DKK1），IL-6，胰岛素，瘦素，TNFα，骨质疏松蛋白（OPG），骨钙素（OC），骨桥蛋白（OPN），硬化蛋白（SOST），IL-1β，甲状旁腺素（PTH）和FGF-23。该试剂盒采用96孔板，包含冻干标准混合物、两个内部检测质控品，可最多可测定38份样本，重复两次。

Luminex^® xMAP^®平台使用磁珠免疫分析格式，以实现理想的速度和灵敏度，同时定量多种分析物，从而显著提高生产力，同时节省宝贵的样本量。

面板类型：骨

应用

分析物：ACTH、DKK-1、FGF-23、IL-1β、IL-6、胰岛素、瘦素、骨钙素（OC）、骨桥蛋白（OPN）、骨保护素（OPG）、PTH、硬化蛋白（SOST）、TNFα
推荐的样品类型：人血清，血浆和细胞/组织培养上清液或提取物
建议的样品稀释度：每孔25μL d1:2稀释的血清或血浆；细胞/组织培养样品可以直接使用或在适当的对照培养基中稀释使用
分析运行时间：在2-8℃下过夜（16-18小时）或在室温（20-25℃）下2小时。
研究类别：代谢
研究子类别：骨

生化/生理作用

交叉反应
对于该面板中的分析物，未观察到抗体之间的交叉反应性。

特点和优势

通过在此面板中选择可用的分析物来设计多重试剂盒。

其他说明

替代：HBN1B-51K

灵敏度：有关单个分析物的灵敏度，请参见试剂盒方案。

请联系技术服务部进行稀释度线性研究。

法律信息

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

象形图

GHS06,GHS08,GHS05,GHS09

警示用语：

Danger

危险声明

H302 + H332,H311,H317,H318,H373,H411

预防措施声明

P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314

危险分类

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

靶器官

Respiratory Tract

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

法规信息

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Nitrogen Containing Bisphosphonates Impair the Release of Bone Homeostasis Mediators and Matrix Production by Human Primary Pre-Osteoblasts.

Chiara Giannasi et al.

International journal of medical sciences, 16(1), 23-32 (2019-01-22)

Bisphosphonates (BPs) represent the first-line treatment for a wide array of bone disorders. Despite their well-known action on osteoclasts, the effects they induce on osteoblasts are still unclear. In order to shed light on this aspect we evaluated the impact

Circulatory Levels of RANKL, OPG, and Oxidative Stress Markers in Postmenopausal Women With Normal or Low Bone Mineral Density.

Fawaz Y Azizieh et al.

Biomarker insights, 14, 1177271919843825-1177271919843825 (2019-08-28)

Receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), and oxidative stress markers are suggested to contribute to bone loss in osteoporosis that occurs in menopause. However, the association between these markers and bone mineral density (BMD) is controversial.

Chronic binge alcohol administration impairs glucose-insulin dynamics and decreases adiponectin in asymptomatic simian immunodeficiency virus-infected macaques.

Stephen M Ford et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 311(5), R888-R897 (2016-11-03)

Alcohol use disorders (AUDs) frequently exist among persons living with HIV/AIDS. Chronic alcohol consumption, HIV infection, and antiretroviral therapy (ART) are independently associated with impairments in glucose-insulin dynamics. Previous studies from our laboratory have shown that chronic binge alcohol (CBA)

Acute responses of bone specific and related markers to maximal eccentric exercise of the knee extensors and flexors in young men.

Tsang-Hai Huang et al.

Journal of musculoskeletal & neuronal interactions, 20(2), 206-215 (2020-06-03)

The present study determined time-course changes in plasma bone-specific and -related markers following a bout of maximal eccentric contractions (MaxEC) of bilateral knee extensors (KE) and flexors (KF). Sedentary young men (n=30) performed a bout of 10 sets of 10

Multicentric carpotarsal osteolysis syndrome (MCTO) with generalized high bone turnover and high serum RANKL: Response to denosumab.

Ravit Regev et al.

Bone reports, 14, 100747-100747 (2021-01-29)

MCTO is a rare disorder, caused by mutations in the MafB gene, a negative regulator of receptor activator of nuclear factor-кB ligand (RANKL). Manifestations include carpal and tarsal osteolysis and renal failure. Pathophysiology is poorly understood, and no effective treatment

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MILLIPLEX^® 人骨磁珠板 - 骨代谢多重检测