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HCYP3MAG-63K

MILLIPLEX® Human Cytokine/Chemokine Panel 3

Configurable Human Cytokine/Chemokine 11-Plex Panel 3

Synonym(s):

Human cytokine multiplex kit, Luminex® human cytokine immunoassay, Millipore human cytokine panel

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Key Documents

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Product Name

MILLIPLEX® Human Cytokine/Chemokine Panel 3, Configurable Human Cytokine/Chemokine 11-Plex Panel 3

species reactivity

human

Quality Level

200

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

accuracy: 92-106%
standard curve range: 2.0-200,000 pg/mL

technique(s)

multiplexing: suitable

input

cell culture supernatant
serum

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 11 analytes in human serum, plasma, and cell culture supernatants.Analytes included: GCP2, HCC-1, I-TAC, IL-11, IL-29, Lymphotactin, M-CSF, MIG, MIP-3α, MIP-3β, NAP2Note: HCC-1/CCL14a and NAP-2/CXCL7 cannot be plexed with other analytes for serum/plasma.Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

Targeted Multiplex Profiling: Simultaneously quantify 11 cytokines/chemokines (e.g., MIP-3α, IL-29, M-CSF) linked to metabolic disorders, obesity, and autoimmune mechanisms, enabling focused study of immune-inflammatory pathways.Luminex® xMAP® Technology: Magnetic bead-based multiplexing ensures high sensitivity and throughput with minimal sample volume (serum, plasma, or culture supernatants).Configure Your Panel: Select specific analytes (e.g., I-TAC, Lymphotactin) to tailor assays to your research needs, reducing costs and optimizing efficiency.Optimized Sample Dilutions: Run most analytes neat (except NAP-2 and HCC-1, requiring 1:100 dilution for serum/plasma), simplifying workflow for diverse sample types.Accelerate Translational Insights: Investigate chemokine networks in metabolic syndrome or autoimmune diseases and uncover therapeutic targets (e.g., IL-29 in viral responses, M-CSF in macrophage activation).

General description

Cytokines are versatile signaling molecules that regulate immune cell communication, inflammation, and tissue homeostasis. In metabolic and autoimmune disorders, dysregulated cytokine networks drive chronic inflammation, insulin resistance, and tissue damage. Chemokines, a subset of cytokines, direct immune cell migration to sites of injury or infection, while growth factors like M-CSF modulate cell proliferation and repair. In obesity, pro-inflammatory cytokines exacerbate adipose tissue dysfunction, whereas in autoimmune diseases, they promote aberrant immune activation against self-tissues. Conversely, anti-inflammatory cytokines work to restore equilibrium, highlighting their dual role as both drivers of pathology and potential therapeutic targets. Understanding these dynamic interactions is key to developing interventions for conditions ranging from IBD to metabolic syndrome.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

10 - Combustible liquids

Regulatory Information

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Marie L Landry et al.
The Journal of infectious diseases, 217(6), 897-905 (2017-12-28)
Despite the high burden of respiratory infection and the importance of early and accurate diagnosis, there is no simple diagnostic test to rule in viral infection as a cause of respiratory symptoms. We performed RNA sequencing on human nasal epithelial
Pegah Mir Seyed Nazari et al.
Cancers, 11(12) (2019-12-19)
A tight interplay between inflammation and hemostasis has been described as a potential driver for developing venous thromboembolism (VTE). Here, we investigated the association of systemic cytokine levels and risk of VTE in patients with glioma. This analysis was conducted
Matthew S Godwin et al.
American journal of physiology. Lung cellular and molecular physiology, 320(3), L393-L404 (2020-12-17)
Individuals that present with difficult-to-control asthma and sensitivity to one or more fungal species are categorized as a subset of severe asthma patients belonging to a group herein referred to as severe asthma with fungal sensitization (SAFS). We have previously
Alice L den Hertog et al.
PloS one, 10(6), e0129552-e0129552 (2015-06-27)
Many patients treated for tuberculosis (TB) in low and middle income countries are treated based on clinical suspicion without bacteriological confirmation. This is often due to lack of rapid simple accurate diagnostics and low healthcare provider confidence in the predictive
Kristen M Reeder et al.
Mucosal immunology, 11(5), 1352-1362 (2018-06-17)
Asthmatics sensitized to fungi are reported to have more severe asthma, yet the immunopathogenic pathways contributing to this severity have not been identified. In a pilot assessment of human asthmatics, those subjects sensitized to fungi demonstrated elevated levels of the
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"Multiplex detection is a highly efficient tool for measuring the levels of multiple analytes in a single sample. MILLIPLEX® MAP assay panels provide a complete solution for multiplex detection of analytes within particular research areas using the bead-based Luminex® xMAP® technology. Previously, the only option for analyzing MILLIPLEX® MAP assays required the Luminex 200™ or FLEXMAP 3D® analyzers. With the launch of the MAGPIX® system, MILLIPLEX® MAP magnetic bead assays can be analyzed without the use of lasers or hydrodynamic focusing. The MAGPIX® instrument is a compact, cost-effective multiplexing system based on CCD imaging technology. The MAGPIX® instrument was specifically designed to yield comparable results to the Luminex 200™ instrument. To demonstrate similarity between the two systems, we ran parallel assays using the MILLIPLEX® MAP Human Cytokine/Chemokine Magnetic Bead Panel. Standard curve median fluorescence intensity (MFI) and sample range data are similar between the two instrument systems. Furthermore, sample concentration data between the MAGPIX® and Luminex 200™ systems demonstrate correlation coefficients ≥ 0.97."

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