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HCYTA-60K-PX48

MILLIPLEX® Human Cytokine/Chemokine/Growth Factor Panel A

Premixed Human Cytokine/Chemokine/Growth Factor 48-Plex Panel A

Synonym(s):

Human cytokine multiplex kit, Luminex® human cytokine immunoassay, Millipore human cytokine panel

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About This Item

NACRES:
NA.77
UNSPSC Code:
12161503

Key Documents

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Product Name

MILLIPLEX® Human Cytokine/Chemokine/Growth Factor Panel A, Premixed Human Cytokine/Chemokine/Growth Factor 48-Plex Panel A

Quality Level

200

species reactivity

human

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

technique(s)

multiplexing: suitable

input

cell culture supernatant
serum

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Related Categories

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze 48 analytes in human serum, plasma, and cell culture supernatants.

Analytes included: sCD40L, EGF, Eotaxin/CCL11, FGF-2/FGF-basic, FLT-3L, Fractalkine/CX3CL1, G-CSF, GM-CSF, GROα, IFNα2, IFNγ, IL-1α, IL-1β, IL-1RA, IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12 (p40), IL-12(p70), IL-13, IL-15, IL-17A/CTLA8, IL-17E/IL-25, IL-17F, IL-18, IL-22, IL-27, IP-10/CXCL10, MCP-1/CCL2, MCP-3/CCL7, M-CSF, MDC, MIG/CXCL9, MIP-1α/CCL3, MIP-1β/CCL4, PDGF-AA, PDGF-AB/BB, RANTES/CCL5, TGFα, TNFα, TNFβ/LTA, VEGF-A

Note: RANTES cannot be plexed with other cytokines in this panel due to a required 1:100 dilution of plasma/serum samples. This premixed panel comes with a RANTES bead, so please plan your samples accordingly.

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

  • Lead the Field with 48-Plex Precision: The ability to profile 48 analytes simultaneously means researchers can uncover intricate cytokine interactions and pathways that are essential for understanding complex diseases.
  • Confidence in Results with Cross-Reactivity Testing: Enhanced verification means you can publish your findings with greater assurance, knowing that your data is backed by thorough testing protocols.
  • Disease Profiling Power: Proven utility in profiling immune responses in cancer, sepsis, IBD, and autoimmune diseases. Detects subtle changes in cytokine levels across disease states.
  • High Biological Relevance: Analytes selected for their roles in inflammation, immune regulation, angiogenesis, and cell signaling, including key biomarkers like IL-6, TNFα, IL-10, VEGF-A, and PDGF-BB.
  • Peer-Reviewed Validation: Extensively cited in immunology and disease research publications. Trusted by academic and clinical researchers worldwide.

General description

Cytokines, chemokines, and growth factors are key mediatorsof immune system functions capable of signaling through autocrine, paracrine,and endocrine mechanisms. Their pleiotropic immunomodulatory propertiesallow these biomolecules to react to diverse stimuli and regulate the immuneresponse, either promoting or inhibiting inflammation.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

10 - Combustible liquids

wgk

WGK 3

Regulatory Information

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Kuo-Chu Lai et al.
Journal of cachexia, sarcopenia and muscle, 13(2), 1314-1328 (2022-02-17)
Interferon-induced protein with tetratricopeptide repeat 2 (IFIT2) is a reported metastasis suppressor in oral squamous cell carcinoma (OSCC). Metastases and cachexia may coexist. The effect of cancer metastasis on cancer cachexia is largely unknown. We aimed to address this gap
Xianwen Ren et al.
Cell, 184(7), 1895-1913 (2021-03-04)
A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent immune cells is not complete. We applied single-cell RNA sequencing to 284 samples from 196 COVID-19
Igor V Kudryavtsev et al.
Viruses, 14(9) (2022-09-24)
The adaptive antiviral immune response requires interaction between CD8+ T cells, dendritic cells, and Th1 cells for controlling SARS-CoV-2 infection, but the data regarding the role of CD8+ T cells in the acute phase of COVID-19 and post-COVID-19 syndrome are
Adam J Wolpaw et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(6) (2022-02-06)
Immunotherapy has revolutionized cancer treatment, but many cancers are not impacted by currently available immunotherapeutic strategies. Here, we investigated inflammatory signaling pathways in neuroblastoma, a classically "cold" pediatric cancer. By testing the functional response of a panel of 20 diverse
Austen Terwilliger et al.
Viruses, 13(10) (2021-10-27)
We rationally designed a bacteriophage cocktail to treat a 56-year-old male liver transplant patient with complex, recurrent prostate and urinary tract infections caused by an extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E. coli) (UCS1). We screened our library for phages that
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