MILLIPLEX^® Human Cytokine Autoantibody Panel

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

MILLIPLEX^® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 23 analytes in human serum and plasma samples.Analytes included: Anti-BAFF, Anti-G-CSF, Anti-IFNβ, Anti-IFNγ, Anti-IL-1α, Anti-IL-6, Anti IL 8, Anti-IL-10, Anti-IL-12p40, Anti-IL-15, Anti-IL-17A, Anti-IL-17F, Anti-IL-18, Anti-IL-22, Anti-TNFα, Anti-IFNα2, Anti-GM-CSF, Anti-IL-2, Anti-IL-3, Anti-IL-4, Anti-Osteopontin, Anti-PF4, and Anti-IFNψNote: This is a qualitative assay.Assay Characteristics: Refer to kit protocol for assay cross-reactivity and precision.

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Comprehensive 23-Plex IgG Analysis: Simultaneously analyze 23 IgG cytokine autoantibodies in a single sample, enabling complete assessment of mature immune responses while conserving precious research samples.Established Immune Memory Research: Detect IgG cytokine autoantibodies representing established, long-term immune responses, providing insights into chronic autoimmune processes and persistent immune dysfunction.Chronic Disease Investigation: Study IgG autoantibodies associated with established autoimmune conditions including systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis to understand long-term disease mechanisms.Configurable Panel Design: Choose from available analytes within the panel to create tailored multiplex kits that match specific research objectives and study requirements.Flexible Sample Types: Compatible with both serum and plasma samples, accomodating various research sample collection protocols and laboratory workflows.

Anti-cytokine antibodies occur frequently and are present in healthy individuals and patients with acquired immunodeficiency and autoimmune diseases. Cytokines offering protection against microbes can be targeted by cytokine autoantibodies, leading to life-threatening infections. Some infections associated with anti-cytokine antibodies include M. tuberculosis, Salmonella, S. aureus. E. coli, Histoplasma, and more. The presence of cytokine autoantibodies in autoimmune disease can influence disease severity and activity. These autoimmune diseases may include systemic lupus erythematosus, multiple sclerosis, Sjögren′s syndrome, rheumatoid arthritis, and acute respiratory distress syndrome.