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Merck
CN

HKI5MAG-99K

MILLIPLEX® Human Kidney Injury Panel

Configurable Human Kidney Toxicity 6-plex Panel 5

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000
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Product Name

MILLIPLEX® Human Kidney Injury Panel,

species reactivity

human

Quality Level

description

Configurable Human Kidney Toxicity 6-plex Panel 5

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

accuracy: 62-90%, intra-assay cv: <10, sensitivity: 0.05-0.56 ng/mL
(MinDC+2SD), standard curve range: 0.05-50 ng/mL
(Lipocalin-2/NGAL), standard curve range: 0.05-50 ng/mL
(Uromodulin), standard curve range: 0.10-100 ng/mL
(TIMP-1), standard curve range: 0.20-200 ng/mL
(Osteoactivin), standard curve range: 0.24-250 ng/mL
(α-1-Microglobulin), standard curve range: 0.49-500 ng/mL
(Collagen IV)

technique(s)

multiplexing: suitable

input

serum

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

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General description

Albumin, Beta-2 Microglobulin, Clusterin, Cystatin C, Lipocalin-2/NGAL, Osteopontin, and Uromodulin are biomarkers associated with kidney function, tubular health, and inflammation. These analytes help detect glomerular damage, proteinuria, and epithelial stress, offering valuable insights into renal injury and disease progression. Their combined measurement supports sensitive evaluation of both acute and chronic kidney conditions

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 6 analytes in human serum or plasma samples.

Analytes included: α-1-Microglobulin, Collagen IV, Lipocalin-2/NGAL, Osteoactivin, TIMP-1, Uromodulin

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

Features:

  • Multiplex Capability: Simultaneous quantification of up to 6 kidney injury biomarkers in a single sample
  • Magnetic Bead-Based Technology: Enables high-throughput and precise analyte detection using Luminex® xMAP® technology
  • Validated for Human Serum and Plasma: Optimized for use with clinically relevant sample types
  • Wide Dynamic Range: Detects low to high concentrations of biomarkers with excellent sensitivity
  • Comprehensive Biomarker Coverage: Includes α-1-Microglobulin, Collagen IV, Lipocalin-2/NGAL, Osteoactivin, TIMP-1, and Uromodulin
  • Flexible Format: Available in a 96-well plate configuration for streamlined workflow integration
Benefits:

  • Efficient Sample Use: Requires minimal sample volume while delivering rich data across multiple biomarkers
  • Accelerated Research: Ideal for translational studies, drug safety assessments, and nephrotoxicity profiling
  • Improved Data Quality: High reproducibility and precision reduce variability and enhance confidence in results
  • Time and Cost Savings: Reduces assay time and reagent consumption compared to singleplex methods

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Regulatory Information

新产品
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Multiplex toxicity assays enable researchers to simultaneously measure multiple toxicity biomarkers of various organs to gain a better understanding of toxicity. Explore how MILLIPLEX® multiplex toxicity assays are advancing research on liver injury, kidney toxicity, genotoxicity, and more.

Novel kidney toxicity biomarkers expand options for acute nephrotoxicity detection. Multiplex assays measure multiple renal damage biomarkers in small sample volumes, minimizing time and costs. See how MILLIPLEX® multiplex kidney toxicity assays detected vancomycin-induced subacute nephrotoxicity in rat models.

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