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HKI6MAG-99K

Millipore

MILLIPLEX® Human Kidney Injury Magnetic Bead Panel 6 - Toxicity Multiplex Assay

The analytes available for this multiplex kit are: β-2-Microglobulin (β2M), Clusterin, Cystatin C, RBP4.

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eCl@ss:
32161000

Quality Level

200

species reactivity

human

manufacturer/tradename

Milliplex®

assay range

accuracy: 103-133%
intra-assay cv: <10
sensitivity: 0.10-3.42 ng/mL
(MinDC+2SD)
standard curve range: 0.05-50 ng/mL
(β-2-Microglobulin (β2M))
standard curve range: 0.10-100 ng/mL
(RBP4)
standard curve range: 0.59-600 ng/mL
(Cystatin C)
standard curve range: 2.93-3,000 ng/mL
(Clusterin)

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex xMAP)

shipped in

wet ice

Related Categories

General description

Maintenance of physiological balance in the body is attributed in part to normal kidney function. Altered kidney function due to injury, drug toxicity or kidney failure may be life threatening. Toxicity is the leading cause of drug failure, so research is expanding in search of more sensitive, rapid methods to determine organ-specific damage as quickly as possible. Traditionally, blood urea nitrogen (BUN) and serum creatinine tests have been used to determine drug-induced damage to the kidney. These tests only detect kidney damage after it begins and do not allow for the elucidation of where in the kidney the damage has occurred. Specificity and earlier detection of kidney injury is vital, and this area of research is expanding in search of more sensitive, rapid methods for determining the specific area of damage in kidney.

The MILLIPLEX® portfolio provides valuable research assays to investigate multiple biomarkers of kidney injury in human serum and plasma samples using the [Luminex® xMAP® instrument platform.

The MILLIPLEX® Human Kidney Injury Bead Panel 6 contains all the components necessary to measure the following four biomarkers in any combination using [Luminex® xMAP® technology: β-2-Microglobulin (β2M), Clusterin, Cystatin C, RBP4. The kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 serum or plasma samples in duplicate.

Panel Type: Toxicity

Specificity

Cross Reactivty
There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel.

Application

  • Analytes: β-2-Microglobulin (β2M), Clusterin, Cystatin C, RBP4
  • Recommended Sample type: serum and plasma
  • Recommended Sample dilution: 1:3,000 in kit Assay Buffer. Customers should determine the optimal dilution factor for their samples. Our recommendations are based on serum and plasma samples from normal subjects.
  • Assay Run Time: Overnight
  • Research Category: Toxicity

Features and Benefits

Design your multiplex kit by choosing available analytes within this panel.

Packaging

Everything you need in a single kit.

Storage and Stability

Recommended storage for kit components is 2 - 8°C.

Other Notes

Please contact Technical Service for linearity of dilution.
Sensitivity: Please see kit protocol for individual assay sensitivities.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

Target Organs

Respiratory Tract

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Regulatory Information

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R Mateo-Gallego et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD, 28(2), 133-142 (2018-01-14)
High-protein (HP) diets have shown benefits in cardiometabolic markers such as insulin or triglycerides but the responsible mechanisms are not known. We aimed to assess the effect of three energy-restricted diets with different protein contents (20%, 27%, and 35%; ∼80%

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