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Merck
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HND3MAG-39K

MILLIPLEX® Human Neuroscience Panel

Configurable Human Neurological Disorders 7-Plex Panel 3

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Key Documents

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species reactivity

human

Quality Level

200

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

accuracy: 69-92%
(Cerebrospinal fluid (CSF)), accuracy: 71-107%
(Serum), standard curve range: 0.03-25 ng/mL
(SOD2), standard curve range: 0.04-30 ng/mL
(Kallikrein-6), standard curve range: 0.04-30 ng/mL
(SOD1), standard curve range: 0.08-60 ng/mL
(Contactin-1), standard curve range: 0.14-100 ng/mL
(Osteopontin (OPN)), standard curve range: 1.37-1,000 ng/mL
(AGT), standard curve range: 4.12-3,000 ng/mL
(Fetuin A)

technique(s)

multiplexing: suitable

input

cerebrospinal fluid(s) (CSF)
serum

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

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General description

Oxidative damage is a hallmark of many neurological disorders. SOD1 and SOD2 neutralize reactive oxygen species and are implicated in conditions like ALS. Osteopontin rises in stroke and Alzheimer′s, reflecting inflammatory stress. Kallikrein-6 has emerged as a candidate marker for multiple sclerosis, while contactin-1, fetuin A, and angiotensinogen contribute to neuronal signaling, metabolic balance, and vascular regulation—each offering clues to disease progression.

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 7 analytes in human serum, plasma, and cerebrospinal fluid (CSF).

Analytes included: Angiotensinogen (AGT), Contactin-1, Fetuin A, Kallikrein-6, Osteopontin (OPN), soluble Superoxide Dismutase 1 (SOD1), soluble Superoxide Dismutase 2 (SOD2).

Note: When testing serum/plasma samples, Fetuin A cannot be plexed with other analytes in this panel due to a required 1:40,000 dilution. The other 6 analytes can be assayed together as a multiplex when testing serum/plasma samples but Fetuin A must be tested as a singleplex.

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Features and Benefits

  • Comprehensive Oxidative Stress Assessment: Simultaneously quantify SOD1 and SOD2 antioxidant enzymes alongside inflammatory markers, providing complete oxidative stress profiling critical for understanding neurodegeneration mechanisms.

  • Cross-Disease Research Power: Leverage biomarkers relevant to ALS, Alzheimer′s disease, stroke, and multiple sclerosis in one panel, maximizing research impact and enabling comparative studies across neurological conditions.

  • Dual-Protocol Flexibility: Choose between overnight and 2-hour protocols to match your research timeline needs, with both delivering < 10% precision and excellent spike recovery across multiple sample types.

  • Multi-Sample Compatibility: Analyze CSF, serum, and plasma samples with optimized performance, maximizing research versatility and enabling comprehensive biomarker studies across different biological matrices.

  • Streamlined Neurological Research: Eliminate the complexity of seven separate assays with our integrated 7-plex format, accelerating your neuroscience discoveries while preserving precious samples for comprehensive protein profiling.

Legal Information

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

10 - Combustible liquids

wgk

WGK 3

Regulatory Information

新产品
This item has

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Teresa Nestares et al.
Nutrients, 13(1) (2021-01-10)
The current study was designed to assess the influence of consumption of ultra-processed (UPF) on oxidative/antioxidant balance and evoked inflammatory signaling in young patients with celiac disease (CD). The study included 85 children. The celiac group (n = 53) included
Javier Diaz-Castro et al.
European journal of nutrition, 59(4), 1577-1584 (2019-05-31)
Celiac disease (CD) is a multifactorial, autoimmune, gluten-sensitive inflammatory disorder of the small intestine. Taking into account the pathogenesis of CD, a strict gluten-free diet (GFD) is the only treatment able to restore epithelium integrity and eliminate complications. The current

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