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HNDG2MAG-36K

MILLIPLEX® Human Neurodegenerative Disease Panel

Configurable Human Neurodegenerative Disease 6-Plex Panel 2

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.84
eCl@ss:
32161000

Key Documents

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Product Name

MILLIPLEX® Human Neurodegenerative Disease Panel, Configurable Human Neurodegenerative Disease 6-Plex Panel 2

species reactivity

human

Quality Level

200

packaging

pkg of 1 ea

manufacturer/tradename

Milliplex®

assay range

accuracy: 84%
(SAP)
accuracy: 88%
(Complement C4)
accuracy: 92%
(α-1-Antitrypsin)
accuracy: 92%
(PEDF)
accuracy: 95%
(MIP-4)
standard curve range: 0.05-200 ng/mL
(PEDF)
standard curve range: 0.10-50 ng/mL
(CRP)
standard curve range: 0.12-500 ng/mL
(SAP)
standard curve range: 0.24-1,000 ng/mL
(α-1-Antitrypsin)
standard curve range: 0.24-1,000 ng/mL
(Complement C4)
standard curve range: 4.88-20,000 ng/mL
(MIP-4)

technique(s)

multiplexing: suitable

input

cerebrospinal fluid(s) (CSF)
serum
cell culture supernatant

detection method

fluorometric (Luminex® xMAP® technology)

shipped in

wet ice

storage temp.

2-8°C

Legal Information

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
Luminex is a registered trademark of Luminex Corp
xMAP is a registered trademark of Luminex Corp

Application

MILLIPLEX® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 6 analytes in human serum, plasma, and cerebrospinal fluid (CSF).Analytes included: CRP, α1-antitrypsin, PEDF, SAP, MIP-4, Complement C4.Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.Label License/Sticker for Assay Product:By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

Acute Phase Response Profiling: Simultaneously quantify CRP, SAP, and α1-antitrypsin to capture comprehensive inflammatory responses and immune system activation patterns critical for neurodegeneration research.Sample Type Flexibility: Analyze serum, plasma, and cerebrospinal fluid samples with validated performance, enabling comprehensive biomarker studies across diverse biological specimens and research applications.Batch-to-Batch Consistency: Trust in stringent manufacturing standards and quality controls that ensure reproducible results across different kit lots, supporting longitudinal studies and multi-site collaborations.Expert Scientific Partnership: Access dedicated field application scientists and technical support teams who provide can specialized multiplex assay guidance.Configurable Research Solutions: Design your ideal biomarker panel by selecting any combination of the 6 analytes, creating tailored assays that perfectly align with your specific research hypotheses and objectives.

General description

Inflammatory cascades in the brain are shaped by acute phase proteins and complement activity. CRP and SAP accumulate in amyloid plaques and signal systemic inflammation. α1-Antitrypsin tempers protease activity and may dampen microglial overactivation, offering a protective buffer against amyloid-beta toxicity. PEDF contributes neuroprotective and anti-angiogenic effects, while complement C4 supports immune surveillance and debris clearance in neurodegenerative contexts.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

10 - Combustible liquids

wgk

WGK 3

Regulatory Information

新产品
This item has

Certificates of Analysis (COA)

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Aziza Al-Rafiah et al.
BioMed research international, 2021, 3081891-3081891 (2021-10-30)
Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Amphetamine addiction may cause serious of psychotic and physical damage to humans. There is some evidence that shows that amphetamine may increase the risk of PD. Thus, this study
Sean J Lee et al.
Journal of clinical & experimental ophthalmology, 6(5) (2016-01-26)
Alterations in neuron-glia signaling are implicated in glaucoma, a neurodegenerative disease characterized by retinal ganglion cell (RGC) death. Pigment epithelium derived factor (PEDF) is a secreted protein with potential neuroprotective qualities in retinal disease, including chronic ocular hypertension. Here we
Jinxue Wei et al.
Neuropsychiatric disease and treatment, 14, 37-41 (2018-01-06)
Elevation of plasma inflammatory factors in major depressive disorder (MDD) has been repeatedly observed, but contradictory results have also been reported. Alteration of complement components in MDD may also contribute to the pathophysiology of MDD by participating in inflammation. The
Felipe Mallmann et al.
Arquivos brasileiros de oftalmologia, 82(4), 275-282 (2019-04-11)
To compare the intravitreal concentrations of cellular mediators involved in neurodegeneration, inflammation, and angiogenesis in patients with proliferative diabetic retinopathy and other vitreoretinal diseases. A multiplex bead immunoassay was used to measure vitreous levels of pigment epithelium-derived factor, serum amyloid
Abdul Hye et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 10(6), 799-807 (2014-07-12)
The study aimed to validate previously discovered plasma biomarkers associated with AD, using a design based on imaging measures as surrogate for disease severity and assess their prognostic value in predicting conversion to dementia. Three multicenter cohorts of cognitively healthy
View All Related Papers

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