Anti-beta Arrestin 1 Antibody, clone 3H11.2

The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta Arrestin 1), Arrestin 3 (beta Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta Arrestins 1 and 2 are ubiquitously expressed. Beta Arrestins appear to act as negative regulators on G protein-coupled receptors, (Lefkowitz, 1998). Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases, (Lin, 1998; Miller, 2001).

Other species have not been tested.

Reacts with human beta-arrestin 1.

Epitope: a.a. 357-372

KLH conjugated synthetic peptide corresponding to amino acids 357-372 of human beta arrestin 1.

Anti-beta Arrestin 1 Antibody, clone 3H11.2 detects level of beta Arrestin 1 & has been published & validated for use in WB & IF.

Research Category
Cell Structure

Research Sub Category
Sensory & PNS

G-proteins

Evaluated on a representative lot by Western blot in HEK293 cell lysate.

~47 kDa

Format: Purified

Purified in PBS with 0.05% NaN3.

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

Control
HEK293 cell lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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