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MAB3077

Sigma-Aldrich

Anti-G Protein Giα-2 Antibody, clone L5

clone L5, Chemicon®, from mouse

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eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

L5, monoclonal

species reactivity

bovine, mouse, human, rat, guinea pig

manufacturer/tradename

Chemicon®

technique(s)

western blot: suitable

isotype

IgG2b

NCBI accession no.

NM_002070.2

UniProt accession no.

P04899

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... GNAI2(2771)

Specificity

Gialpha-2. Strong reactivity with bovine (100%), mouse (69%), rat (69%), human (62%) and guinea pig (43%). Specificity confirmed by Western blot versus bovine Galphat, rat Goalpha, rat Gialpha-1, Gialpha-2, rat Gialpha-3, bovine Gsalpha, and murine GoalphaA and GoalphaB.

Immunogen

Recombinant Gialpha-2, purified by the method of Linder (1990).

Application

Anti-G Protein Giα-2 Antibody, clone L5 is an antibody against G Protein Giα-2 for use in WB.
Research Category
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
Western blot 1:500 - 1:1000, with detection by 125I-labeled anti-IgG.

Labels a single protein band of 39 - 42 kDa in bovine and rat membranes.

Optimal working dilutions must be determined by end user.

Physical form

Format: Purified
Purified immunoglobulin, in 0.02M phosphate buffer, 0.25M sodium chloride, pH 7.6, with 0.1% sodium azide.

Storage and Stability

Maintain at 2-8°C.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Hiromi Ohara et al.
The Journal of veterinary medical science, 75(1), 85-88 (2012-08-11)
In rodents, Gα(i2)-expressing sensory neurons (SNs) that co-express vomeronasal receptor type 1 (V1R) are specifically found in the vomeronasal organ (VNO) and project their axons to the accessory olfactory bulb (AOB). In goats, however, Gα(i2)/V1R-expressing SNs exist in both the
Kati S Mönkkönen et al.
Human reproduction (Oxford, England), 22(5), 1224-1230 (2007-03-10)
Heterotrimeric G proteins take part in membrane-mediated cell signalling and have a role in hormonal regulation. This study clarifies the expression and localization of the G protein subunit G alpha(i2) in the human endometrium and Fallopian tube and changes in
J T O'Flaherty et al.
Journal of immunology (Baltimore, Md. : 1950), 164(6), 3345-3352 (2000-03-08)
5-Oxo-eicosatetraenoic acid (5-oxoETE) stimulated human neutrophil (PMN) and eosinophil chemotaxis, PMN hexose uptake, and PMN membrane GTP/GDP exchange. Pertussis toxin (PT), a blocker of heterotrimeric G proteins (GP), completely inhibited these responses, but proved far less effective on the same
Raghu Ram Katreddi et al.
Development (Cambridge, England), 149(13) (2022-07-06)
The ability of terrestrial vertebrates to find food and mating partners, and to avoid predators, relies on the detection of chemosensory information. Semiochemicals responsible for social and sexual behaviors are detected by chemosensory neurons of the vomeronasal organ (VNO), which
Jennifer M Lin et al.
eLife, 11 (2022-09-17)
Neuronal identity dictates the position in an epithelium, and the ability to detect, process, and transmit specific signals to specified targets. Transcription factors (TFs) determine cellular identity via direct modulation of genetic transcription and recruiting chromatin modifiers. However, our understanding
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