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Merck
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MABC1036

Anti-EphA7 Antibody, clone 2F3.1

clone 2F3.1, from mouse

Synonym(s):

Ephrin type-A receptor 7, EHK-3, EK11, EPH homology kinase 3, EPH-like kinase 11, hEK11, Receptor protein-tyrosine kinase HEK11, Tyrosine-protein kinase receptor EHK-3

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

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Product Name

Anti-EphA7 Antibody, clone 2F3.1, clone 2F3.1, from mouse

isotype

IgG2aκ

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2F3.1, monoclonal

species reactivity

human

technique(s)

western blot: suitable

NCBI accession no.

NP_004431

UniProt accession no.

Q15375

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... EPHA7(2045)

Analysis Note

Evaluated by Western Blotting in MCF-7 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected EphA7 in 10 µg of MCF-7 cell lysate.

Application

Anti-EphA7 Antibody, clone 2F3.1 is an antibody against EphA7 for use in Western Blotting.
Research Category
Apoptosis & Cancer
Research Sub Category
Cytokines & Cytokine Receptors

Biochem/physiol Actions

Expected to react with all five spliced isoforms of human EphA7 reported by UniProt (Q15375).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Ephrin type-A receptor 7 (EC 2.7.10.1; UniProt Q15375; also known as EHK-3, EK11, EPH homology kinase 3, EPH-like kinase 11, hEK11, Receptor protein-tyrosine kinase HEK11, Tyrosine-protein kinase receptor EHK-3) is encoded by the EPHA7 (also known as EHK3, HEK11) gene (Gene ID 2045) in human. EphA7 belongs to the ephrin receptor family of receptor tyrosine kinases that are activated upon ephrin binding. Ephrin receptor signaling plays important roles in embryonic development, tissue boundaries formation, angiogenesis, stem cell differentiation, and cancer. There exist nine type-A (EphA1-8 and EphA10) and five type-B (EphB1-4 and EphB6) ephrin receptors in human. EphA7 is initially produced with a signal peptide (a.a. 1-27) sequence, the removal of which yields the mature protein with a large extracellular (a.a. 28-555) region, followed by a transmembrane segment (a.a. 556-576) and a cytoplasmic region (a.a. 577-998) that contains the kinase domain (a.a. 633-894).
~120 kDa observed. 112.1 kDa (isoform 1; EPHA7-FL), 111.5 kDa (isoform 2), 31.83 kDa (isoform 3), 111.6 kDa (isoform 4), and 50.52 kDa (isoform 5; EPHA7-S) calculated.

Immunogen

Epitope: Extracellular domain.
GST-tagged recombinant extracellular N-terminal fragment of human EphA7.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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