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Merck
CN

MABC158

Anti-hyaluronan synthase 1 Antibody, clone 12A2.3

clone 12A2.3, from mouse

Synonym(s):

Hyaluronan synthase 1, Hyaluronate synthase 1, Hyaluronic acid synthase 1, HA synthase 1, HuHAS1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Key Documents

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

12A2.3, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgMκ

NCBI accession no.

NP_001514

UniProt accession no.

Q92839

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... HAS1(3036)

General description

Hyaluronan synthase 1 (HAS1) is one of three enzymes, located at the plasma membrane, that synthesizes the glycosaminoglycan hyaluronan or hyaluronic acid (HA). Hyaluronan is involved in cell proliferation, differentiation, angiogenesis, and tumor development, among other cellular processes.
~70 kDa observed

Immunogen

Epitope: Cytoplasmic domain
KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human hyaluronan synthase 1.

Application

Anti-hyaluronan synthase 1 Antibody, clone 12A2.3 is a highly specific mouse monoclonal antibody, that targets Hyaluronan synthase 1 & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected hyaluronan synthase 1 in human ovarian cancer tissues.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional

Biochem/physiol Actions

This antibody recognizes the cytoplasmic domain of hyaluronan synthase 1.

Physical form

Format: Purified
Purified mouse IgMκ supernatant in buffer containing PBS with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
HL-60 cell lysate
Evaluated by Western Blotting in HL-60 cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detects hyaluronan synthase 1 in 10 µg of HL-60 cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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André L Samson et al.
Cell death and differentiation, 28(7), 2126-2144 (2021-02-17)
Necroptosis is a lytic, inflammatory cell death pathway that is dysregulated in many human pathologies. The pathway is executed by a core machinery comprising the RIPK1 and RIPK3 kinases, which assemble into necrosomes in the cytoplasm, and the terminal effector

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