Anti-FYVE Antibody, clone 7F11.1

FYVE, also known as Zinc finger FYVE domain-containing protein 26, or FYVE domain-containing centrosomal protein (FYVE-CENT), or Spastizin, and encoded by the gene ZFYVE26/KIAA0321, is a phosphosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis. FYVE is recruited to the midbody during cytokinesis and acts as a regulator of abscission. FYVE also be required for efficient homologous recombination DNA double-strand break repair. FYVE is cytoskeleton associated and localized in the cytoplasm in resting cells but at the centrosome during cell division. FYVE is expressed in all cells and tissues. Defects in FYVE may be associated with Spastic paraplegia 15, a form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.

~285 kDa calculated. Four isoforms are known to exist at 285 kDa (isoform 1), 283 kDa (isoform 2), 78 kDa (isoform 3), and 89 kDa (isoform 4).

GST-tagged recombinant protein corresponding to human FYVE.

Anti-FYVE Antibody, clone 7F11.1 detects level of FYVE & has been published & validated for use in FYVE.

Immunohistochemisty Analysis: A 1:50 dilution from a representative lot detected FYVE in human frontal cortex and thalamus tissues.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Evaluated by Immunohistochemistry in human cerebellum tissue.

Immunohistochemisty Analysis: A 1:50 dilution from a representative lot detected FYVE in human cerebellum tissue.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.