Anterior gradient protein 2 homolog (AGR2) (also known as secreted cement gland protein XAG-2 homolog) is thought to be a metastasis-inducing protein in breast cancer models and may be used as a means of detecting the outcome of hormonally treated patients with breast cancer. AGR2 may also play an important role in intestinal mucus production. Recent researched has also linked AGR2 to metastasis. Lower levels of AGR expression in prostate cancer may be highly predictive of the reoccurrence of disease even after a prostatectomy.

Specific for Anterior gradient protein 2 homolog and does not detect Anterior gradient protein 3 homolog.

Linear peptide corresponding to a sequence unique to human Anterior gradient protein 2 homolog and not to human Anterior gradient protein 3 homolog.

Anti-Anterior gradient protein 2 homolog Antibody, clone 7A10 is an antibody against Anterior gradient protein 2 homolog for use in WB & IC.

Immunocytochemistry Analysis: A previous lot was used by an independent laboratory in IC on primary carcinomas (Barraclough, D., et al. (2009). Am J Pathol. 175:1848–1857).

Research Category
Apoptosis & Cancer

Research Sub Category
Tumor Markers

Evaluated by Western Blot in MCF-7 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Anterior gradient protein 2 homolog in 10 µg of MCF-7 cell lysate.

~18 kDa observed

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Control
MCF-7 cell lysate

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.