Key Documents

View All Documentation

MABC60

Anti-KiSS-1 Antibody, clone 8H4.1

Name: Anti-KiSS-1 Antibody, clone 8H4.1
Brand: MM

clone 8H4.1, from mouse

Synonym(s):

Metastasis-suppressor KiSS-1, Kisspeptin-1, Metastin, Kisspeptin-542, Kisspeptin-143, Kisspeptin-134, Kisspeptin-10

Select a Size

Change View

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

8H4.1, monoclonal

Application:

IHC, WB

Citations:

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

mouse

Quality Segment

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

8H4.1, monoclonal

species reactivity

human, rat

technique(s)

immunohistochemistry: suitable, western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_002247

UniProt accession no.

Q15726

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... KISS1(3814)

Description

General description

15 kDa calculated

Metastasis-suppressor KiSS-1 (KiSS-1; or Kisspeptin-1) is one of several endogenous ligands for the orphan G-protein coupled receptor GPR54. KiSS-1 functions as a suppressor of metastasis in various types of cancers, by inhibiting migration and proliferation in affected cells. This effect may be produced by the activation of multiple signaling pathways: Ligand-bound GPR54 activates IP3 and PKC signaling via a PLC pathway; and ERK 1 and ERK 2 by a cPLA2, which may lead to increased calcium signaling and gene transcription, respectively. More recently, however, KiSS-1/GPR54 signaling has been implicated in puberty and development. KiSS-1/GPR54 may regulate signaling of GnRH neurons during puberty and may influence the release of FH and LSH hormones. KISS-1 is highly expressed in the CNS, testis, pancreas, intestine, ovary, and placenta.

Immunogen

Recombinant protein corresponding to human KiSS-1.

Application

Anti-KiSS-1 Antibody, clone 8H4.1 is an antibody against KiSS-1 for use in IHC, Western Blotting.

Immunohistochemistry Analysis: 1:1,000 dilution from a representative lot detected KiSS-1 in human pancreas and rat testis tissues.

Physical form

Format: Purified

Analysis Note

Evaluated by Immunohistochemistry in human placenta tissue.

Immunohistochemistry Analysis: 1:1,000 dilution of this antibody detected KiSS-1 in human placenta tissue.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Still not finding the right product?

Try our Product Selector Tool to narrow your options

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c