MABF106
Anti-Viperin Antibody, clone MaP.VIP
clone MaP.VIP, from mouse
Synonym(s):
Radical S-adenosyl methionine domain-containing protein 2, Cytomegalovirus-induced gene 5 protein, Viperin, Virus inhibitory protein,endoplasmic reticulum-associated, interferon-inducible
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
MaP.VIP, monoclonal
Application:
FACS, ICC, IHC, IP, WB
Citations:
21
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
MaP.VIP, monoclonal
species reactivity
human, rat, mouse
technique(s)
flow cytometry: suitable, immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... RSAD2(91543)
General description
Virus inhibitory protein endoplasmic reticulum-associated interferon-inducible (Viperin) belongs to the RSAD2 family and is highly inducible by both type I and type II interferons, but little or no induction is observed in moncytic cell lines. Studies suggest that viperin is involved in host antiviral response, as viperin induction is observed from viral infections. Research also reveals that viperin inhibits influenza replication by disrupting its release from the plasmic membrane through the altering of plasma membrane fluidity by affecting formation of lipid rafts. Lipid rafts are known detergent-resistant microdomian sites for influenza budding.
~42 kDa observed
Immunogen
Recombinant protein corresponding to human Viperin.
Application
Anti-Viperin Antibody, clone MaP.VIP detects level of Viperin & has been published & validated for use in WB, IH, FC, IP & IC.
Immunohistochemistry Analysis: A 1:500-1:1,000 dilution from a representative lot detected Viperin in human colon and rat liver tissues.
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in HepG2 cell lysate (Hinson, E., et al. (2008). JBC. 284(7):4705–4712).
Flow Cytometry Analysis: A representative lot was used by an independent laboratory in mouse liver, spleen, lung, and lymph node cells (Hinson, E., et al. (2010). J. Immunol. 184:5723-5731).
Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in mouse spleen cells (Hinson, E., et al. (2010). J. Immunol. 184:5723-5731).
Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in HepG2 cell lysate (Hinson, E., et al. (2008). JBC. 284(7):4705–4712).
Flow Cytometry Analysis: A representative lot was used by an independent laboratory in mouse liver, spleen, lung, and lymph node cells (Hinson, E., et al. (2010). J. Immunol. 184:5723-5731).
Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in mouse spleen cells (Hinson, E., et al. (2010). J. Immunol. 184:5723-5731).
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology
Immunoglobulins & Immunology
Physical form
Protein G Purified
Format: Purified
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Mouse macrophage stimulated with IFN gamma and LPS
Mouse macrophage stimulated with IFN gamma and LPS
Evaluated by Western Blot in mouse macrophage stimulated with IFN gamma and LPS.
Western Blot Analysis: 1 µg/mL of this antibody detected Viperin in 10 µg of mouse macrophage stimulated with IFN gamma and LPS.
Western Blot Analysis: 1 µg/mL of this antibody detected Viperin in 10 µg of mouse macrophage stimulated with IFN gamma and LPS.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Still not finding the right product?
Try our Product Selector Tool to narrow your options
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Geneviève Pépin et al.
Nucleic acids research, 45(1), 198-205 (2016-10-04)
Acridine dyes, including proflavine and acriflavine, were commonly used as antiseptics before the advent of penicillins in the mid-1940s. While their mode of action on pathogens was originally attributed to their DNA intercalating activity, work in the early 1970s suggested
PIK3CA mutation in endometriotic epithelial cells promotes viperin-dependent inflammatory response to insulin.
Wilson, et al.
Reproductive Biology and Endocrinology, 21, 43-43 (2023)
Sara K Martin et al.
Cell reports, 34(8), 108775-108775 (2021-02-25)
In mammalian cells, specialized DNA polymerase ζ (pol ζ) contributes to genomic stability during normal DNA replication. Disruption of the catalytic subunit Rev3l is toxic and results in constitutive chromosome damage, including micronuclei. As manifestations of this genomic stress are
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MABF106 | 04053252535581 |