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MABN2425

Anti-TRPV2 Antibody, clone 17A11

clone 17A11, from mouse

Synonym(s):

Transient receptor potential cation channel subfamily V member 2, Osm-9-like TRP channel 2, OTRPC2, Stretch-activated channel 2B, Vanilloid receptor-like protein 1, VRL-1

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

17A11, monoclonal

species reactivity

mouse, rat

packaging

antibody small pack of 25 μg

technique(s)

immunocytochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_058903.2

UniProt accession no.

Q9WUD2

target post-translational modification

unmodified

Gene Information

mouse ... Trpv2(22368)
rat ... Trpv2(29465)

Related Categories

General description

86.71 kDa calculated.
Transient receptor potential cation channel subfamily V member 2 (UniProt: Q9WUD2; also known as TrpV2, Osm-9-like TRP channel 2, OTRPC2, Stretch-activated channel 2B, Vanilloid receptor-like protein 1, VRL-1) is encoded by the Trpv2 (also known as Sac2b, Vrl1) gene (Gene ID: 29465) in rat. TrpV2 is an ubiquitously expressed, calcium-permeable, non-selective cation channel with an outward rectification. It has been implicated in various physiological and pathological processes, including growth factor signaling, macrophage migration, cancer cell metastasis, heart disease, and neuronal cell development. It appears to be regulated by growth factors, like IGF1, PDGF, and morphogenetic neuropeptide/head activator. It is also activated by temperatures higher than 52 degree C, but is not activated by vanilloids and acidic pH. TrpV2 channel is upregulated by the nerve growth factor (NGF) via the mitogen-activated protein kinase (MAPK) signaling pathway to augment neurite outgrowth. Although NGF increases TrpV2 content, it does not induce the translocation of TrpV2 from cytoplasm to cell surface in PC12 cells. (Ref.: Cohen MR., et al. (2015). Mol. Cell Biol. 35(24): 4238-4252).

Immunogen

1D4-tagged full length rat Transient receptor potential cation channel subfamily V member 2 (TRPV2).

Application

Anti-TRPV2, clone 17A11, Cat. No. MABN2425, is a highly specific mouse monoclonal antibody that targets TRPV2 and has been tested for use in Immunocytochemistry and Western Blotting.
Western Blotting Analysis: A representative lot detected TRPV2 in Western Blotting applications (Cohen, M.R., et. al. (2013). PLoS One. 8(12):e85392).

Immunocytochemistry Analysis: A representative lot detected TRPV2 in Immunocytochemistry applications (Cohen, M.R., et. al. (2013). PLoS One. 8(12):e85392; Cohen M.R., et. al. (2015). Mol Cell Biol. 35(24):4238-52).

Biochem/physiol Actions

Clone 17A11 detects Transient receptor potential cation channel subfamily V member 2 (TRPV2) in mouse and rat cells.

Physical form

Format: Purified

Analysis Note

Evaluated by Immunocytochemistry in PC12 cells treated with NGF.

Immunocytochemistry Analysis: 2-10 µg/mL of this antibody detected TRPV2 in PC12 cells treated with mouse NGF.

Other Notes

Concentration: Please refer to lot specific datasheet.

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Regulatory Information

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