MABS430
Anti-Mcpip1, clone 2H8.2 Antibody
clone 2H8.2, from mouse
Synonym(s):
Mcpip1, Ribonuclease ZC3H12A, MCP-induced protein 1, Zinc finger CCCH domain-containing protein 12A
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
2H8.2, monoclonal
Application:
IHC, WB
Citations:
-
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
2H8.2, monoclonal
species reactivity
human
technique(s)
immunohistochemistry: suitable (paraffin), western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ZC3H12A(80149)
General description
MCP-induced protein 1 (also known as ribonuclease ZC3H12A, Zinc finger CCCH domain-containing protein 12A) is encoded by the ZC3H12A gene in human (also known as dJ423B22.1, MCPIP, MCPIP1). It belongs to the 4-member CCCH-zinc finger protein family (MCPIP1/2/3/4) that act as negative regulators in macrophage activation (PMID 18178554). MCPIP1 in particular is involved in immune response downregulation upon LPS treatment by targeting IL-6 and IL-12b with its RNase activity (PMID 22561375). MCPIP1 expresssion by MCP-1 treatment is reported to promote angiogenesis in human umbilical vein endothelial cell (HUVEC) cultures, while causing apoptotic cell death in cardiac myocytes (PMID 18364357 & 16574901).
~65 kDa observed
Immunogen
GST-tagged recombinant protein corresponding to human Mcpip1.
Application
Anti-Mcpip1, clone 2H8.2 Antibody is an antibody against Mcpip1 for use in Immunohistochemistry and Immunocytochemistry (Paraffin).
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected MCPIP1 in human kidney tissue.
Physical form
Format: Purified
Analysis Note
Evaluated by Western Blotting in THP-1 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected MCPIP1 in 10 µg of THP-1 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected MCPIP1 in 10 µg of THP-1 cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| MABS430 | 04055977159349 |