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Merck
CN

MABT39

Anti-Laminin alpha 5 Antibody, clone 4B12

clone 4B12, from mouse

Synonym(s):

laminin, alpha 5, Laminin-15 subunit alpha, laminin alpha-5 chain, Laminin-11 subunit alpha, laminin subunit alpha-5, Laminin-10 subunit alpha, Laminin α5, Lamininα5, Laminin-α5

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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Product Name

Anti-Laminin alpha 5 Antibody, clone 4B12, clone 4B12, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

4B12, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable

isotype

IgG1λ

NCBI accession no.

NP_005551

UniProt accession no.

O15230

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... LAMA5(3911)

Analysis Note

Control
Human precancerous colorectal lesion tissue
Evaluated by Immunohistochemistry in human precancerous colorectal lesion tissue.

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Laminin alpha 5 in human precancerous colorectal lesion tissue.

Application

Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Laminin alpha 5 in human blood vessels and metastatic colorectal adenocarcinoma tissues.
Research Category
Cell Structure
Research Sub Category
ECM Proteins
This Anti-Laminin alpha 5 Antibody, clone 4B12 is validated for use in IH for the detection of Laminin alpha 5.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

400 kDa calculated
Laminin alpha 5 (α5) is a member of the laminin family of extracellular matrix glycoproteins. Laminin’s are important in cell migration, differentiation and in tumor cell incursion. Research shows that laminin alpha 5 may be an early marker of sexual differentiation. In rat, the laminin alpha 5 chain seems to halt expression in the basement membrane of Sertoli cells when secretion of AMH begins but expression increases two weeks after birth when AMH secretion stops. Laminin alpha 5 shows up early during lung development in mice. It has also been linked to inflammatory cell chemotaxis and metalloproteinase activity and may play a role in creating and sustaining mucosal patterns of the mouse small intestine.

Immunogen

Laminin purified from human placenta

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1λ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Alberto Pappalardo et al.
Science advances, 9(4), eade2514-eade2514 (2023-01-28)
Despite the advancements in skin bioengineering, 3D skin constructs are still produced as flat tissues with open edges, disregarding the fully enclosed geometry of human skin. Therefore, they do not effectively cover anatomically complex body sites, e.g., hands. Here, we
Aki Natsumi et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 66(12), 847-862 (2018-06-16)
Psoriasis is a complex chronic inflammatory skin disease characterized by epidermal thickening on the basis of increased keratinocyte proliferation and insufficient apoptosis. Laminins are important components of the basement membrane (BM) and impact on epidermal keratinocyte growth/apoptosis. Although several laminins
Shunsuke Iriyama et al.
Scientific reports, 10(1), 12592-12592 (2020-07-30)
Daily sunlight exposure damages the epidermal basement membrane (BM) and disrupts epidermal homeostasis. Inter-follicular epidermal stem cells (IFE-SCs) regulate epidermal proliferation and differentiation, which supports epidermal homeostasis. Here, we examine how photoaging affects the function of IFE-SCs and we identify

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