MABT899
Anti-Mucin 5B Antibody, clone MDA-3E1
clone MDA-3E1, from mouse
Synonym(s):
Mucin 5 subunit B
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
MDA-3E1, monoclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
human, mouse
Citations:
2
Technique(s):
immunohistochemistry: suitable (paraffin)
western blot: suitable
western blot: suitable
Uniprot accession no.:
Product Name
Anti-Mucin 5B Antibody, clone MDA-3E1, clone MDA-3E1, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
MDA-3E1, monoclonal
species reactivity
human, mouse
packaging
antibody small pack of 25 μL
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
ambient
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Muc5B(74180)
Related Categories
Application
Immunohistochemistry Analysis: A representative lot detected Muc5b in Immunohistochemistry applications (Ren, B., et. al. (2015). Biosci Rep. 35(3), e00220).
Western Blotting Analysis: A representative lot detected Muc5b in Western Blotting applications (Ren, B., et. al. (2015). Biosci Rep. 35(3); e00220).
Western Blotting Analysis: A representative lot detected Muc5b in Western Blotting applications (Ren, B., et. al. (2015). Biosci Rep. 35(3); e00220).
Research Category
Inflammation & Immunology
Inflammation & Immunology
Anti-Mucin 5B, clone MDA-3E1 , Cat. No. MABT899, is a mouse monoclonal antibdoy that detects Mucin 5b and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
Biochem/physiol Actions
Clone MDA-3E1 detects Mucin 5b in human and murine species, it targets an epitope within 20 amino acids from the N-terminal half.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
515.44 kDa calculated. The actual molecular weight of the glycosylated protein may be up to 10-fold higher.
Mucin 5, subtype B, tracheobronchial (UniProt: E9Q5I3; also known as MUC5B ) is encoded by the Muc5b gene (Gene ID: 74180) in murine species. Mucins are high molecular weight glycoproteins that consist of a mucin core protein and O-linked carbohydrates. Mucins are present on the surface of, and are secreted by, many glandular epithelial cells. They provide a barrier between the luminal membranes of cells in the epithelium and their environment. Mucins consist of a nonglobular protein backbone (apomucin) and many O-linked glycans. The two principal polymeric mucins are reported in the airways. They are Mucin 5ac that is produced at low levels under healthy conditions, but increases during allergic inflammation or parasitic infection, and Mucin 5B that is produced at substantial levels under healthy conditions and modestly increases under conditions of allergic inflammation Mucin 5B is shown to be abnormally expressed in gastric carcinoma. (Ref.: Ren, B et al. (2015). (Biosci Rep. 35(3): e00220).
Immunogen
A linear peptide corresponding to 20 amino acids from the N-terminal half of murine Mucin 5 subunit B.
Other Notes
Concentration: Please refer to lot specific datasheet.
Physical form
Format: Purified
Protein G purified
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Immunohistochemistry in human nasal mucosal tissue.
Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Muc5b in human nasal mucosal tissue.
Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Muc5b in human nasal mucosal tissue.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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David L Goldblatt et al.
British journal of pharmacology, 177(10), 2256-2273 (2020-01-23)
Respiratory viral infections play central roles in the initiation, exacerbation and progression of asthma in humans. An acute paramyxoviral infection in mice can cause a chronic lung disease that resembles human asthma. We sought to determine whether reduction of Sendai
Leticija Zlatar et al.
Cells, 12(14) (2023-07-29)
Mucopeptide concretions, previously called dacryoliths, are macroscopic stones that commonly obstruct the lacrimal sac. The mechanism behind dacryolithiasis remains unclear; however, the involvement of various immune cells, including neutrophils, has been confirmed. These findings remain limited, and no information on
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