MILLIPLEX^® Mouse MMP Panel

The MMPs (matrix metalloproteinases), a family of zinc proteases responsible for the breakdown of extracellular matrix (ECM), play a key role in normal physiological processes, such as embryonic development and tissue morphogenesis, tissue and bone remodeling, wound healing, and angiogenesis. These processes rely on MMPs′ role in the cleavage of cell surface receptors, the release of apoptotic ligands, cell proliferation and differentiation, and chemokine activity modulation. Similar in structure, MMPs are synthesized and secreted as inactive pro-enzymes that require proteolytic cleavage for activation. This process can be mediated by serine proteases or other MMPs. An increase in MMP expression occurs in response to a wide range of stimuli, including adhesion molecules, growth factors, cytokines, and hormones. Regulation of MMP activity is controlled primarily by TIMPs (tissue inhibitors of metalloproteinases). Therefore, disruption of the MMP/TIMP balance can result in autoimmune disease, arthritis, cardiovascular disease, and tumor growth and metastasis.

MILLIPLEX^® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 5 analytes in mouse cell culture supernatants.

Analytes included: MMP-2, MMP-3, MMP-8, proMMP-9, MMP-12

Assay Characteristics: Refer to kit protocol for assay cross-reactivity, sensitivity, precision, and accuracy.

5-Plex Multiplex Assay: Simultaneous detection of MMP-2, MMP-3, MMP-8, proMMP-9, and MMP-12 in a single sample. Enables comprehensive profiling of matrix metalloproteinase activity.

Optimized for Tissue Culture Samples: Validated for use with cell/tissue culture supernatants and extracts, ideal for in vitro studies.

Comprehensive ECM Remodeling Insight: MMPs play a central role in tissue morphogenesis, wound healing, angiogenesis, and immune regulation. This panel enables researchers to monitor key enzymes involved in these processes.

Supports Disease Research: Ideal for investigating autoimmune diseases, arthritis, cardiovascular conditions, and tumor progression, where MMP dysregulation is implicated.

Efficient Sample Use: Multiplexing reduces sample volume and reagent consumption, saving time and resources.

High Sensitivity & Specificity: Detects both active and pro-forms of MMPs, providing deeper insight into enzyme activation dynamics.

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.