RV1MAG-26K

MILLIPLEX^® Rat Vascular Injury Panel

Name: MILLIPLEX<SUP>®</SUP> Rat Vascular Injury Panel
Brand: MM

Configurable Rat Vascular Injury 9-Plex Panel 1

Synonym(s):

Luminex^® Rat Vascular Injury Panel, Millipore Rat Vascualr Injury Panel, Rat Vascular Injury Multiplex Assay

About This Item

UNSPSC Code:

12161503

NACRES:

NA.84

eCl@ss:

32161000

Key Documents

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Product Name

MILLIPLEX^® Rat Vascular Injury Panel, Configurable Rat Vascular Injury 9-Plex Panel 1

packaging

1 ea of

assay range

accuracy: 97-108%
intra-assay cv: <10%
standard curve range: 0.1-100 ng/mL
(CINC-1/GRO/KC, IL-6, MCP-1, PAI-1 (total))
standard curve range: 0.1-15 ng/mL
(VEGF)
standard curve range: 0.1-20 ng/mL
(TNFα)
standard curve range: 0.2-150 ng/mL
(TIMP-1)
standard curve range: 0.3-200 ng/mL
(CTGF)
standard curve range: 1.4-1,000 ng/mL
(Caveolin-1)
inter-assay cv: <10%
(All other analytes)
inter-assay cv: <15%
(CINC-1/GRO/KC, PAI-1 (total), TIMP-1, TNFα)
inter-assay cv: <20%
(Caveolin-1)

technique(s)

multiplexing: suitable

detection method

fluorometric (Luminex^® xMAP^® technology)

shipped in

wet ice

storage temp.

2-8°C

species reactivity

rat

manufacturer/tradename

Milliplex^®

Quality Level

200

Other Notes

Sensitivity: See kit protocol for individual analytes sensitivities.

Legal Information

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Application

MILLIPLEX^® Qualified assays undergo rigorous assay development, verification, and Quality Control testing to achieve optimal performance. Simultaneously analyze up to 9 analytes in rat serum or plasma samples.

Analytes included: Caveolin-1, CTGF, KC/GRO (CXCL1), IL-6, MCP-1 (CCL2), PAI-1 (Total), TIMP-1, TNFα, VEGF

Assay Characteristics: Refer to assay protocol for details on cross-reactivity, sensitivity, precision, and accuracy.

Disclaimer

For research use only. Not for use in diagnostic procedures.

Label License/Sticker for Assay Product:

By opening the packaging containing this Assay Product (which contains fluorescently labeled microsphere beads authorized by Luminex Corporation) or using this Assay Product in any manner, you are consenting and agreeing to be bound by the End User Terms and Conditions and the End User License Agreement available at http://support.diasorin.com/end-user-terms-and-conditions/. If you do not agree to all of the terms and conditions, you must promptly return this Assay Product for a full refund prior to using it in any manner.

Features and Benefits

Features:

Targets a broad panel of biomarkers involved in vascular injury, inflammation, and tissue remodeling
Includes 9 analytes covering endothelial function, chemokine signaling, cytokine activity, and angiogenesis
Multiplex format enables simultaneous detection from minimal sample volume
Compatible with rat serum, plasma, and tissue culture supernatant samples
Designed for vascular injury, fibrosis, inflammation, and regenerative research

Benefits:

Provides a detailed molecular profile of vascular damage and repair mechanisms
Supports evaluation of therapeutic interventions targeting vascular inflammation and remodeling
Facilitates monitoring of angiogenic and fibrotic responses in preclinical rat models
Enhances understanding of immune cell recruitment and cytokine signaling in vascular pathology
Streamlines experimental workflows with high-throughput, multi-analyte capability

General description

Biomarkers such as Caveolin-1, CTGF, KC/GRO (CXCL1), IL-6, MCP-1 (CCL2), PAI-1 (Total), TIMP-1, TNFα, and VEGF are central to understanding vascular injury, inflammation, and tissue remodeling in rat models. Caveolin-1 regulates endothelial function and vascular permeability, while CTGF is involved in fibrosis and extracellular matrix production. KC/GRO and MCP-1 are chemokines that mediate immune cell recruitment. IL-6 and TNFα are pro-inflammatory cytokines linked to vascular inflammation. PAI-1 and TIMP-1 regulate fibrinolysis and matrix turnover, and VEGF promotes angiogenesis. Together, these analytes provide a comprehensive profile of vascular damage, repair, and inflammatory signaling

pictograms

GHS06,GHS08,GHS05,GHS09

signalword

Danger

hcodes

H302 + H332,H311,H317,H318,H373,H411

pcodes

P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2

target_organs

Respiratory Tract

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

Regulatory Information

新产品

This item has

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Lung-borne systemic inflammation in mechanically ventilated infant rats due to high PEEP, oxygen, and hypocapnia.

Philipp Baumann et al.

American journal of translational research, 14(1), 343-354 (2022-02-18)

Intensive care practice calls for ventilator adjustments due to fast-changing clinical conditions in ventilated critically ill children. These adaptations include positive end-expiratory pressure (PEEP), fraction of inspired oxygen (FiO2), and respiratory rate (RR). It is unclear which alterations in ventilator

Chronic Embolic Pulmonary Hypertension Caused by Pulmonary Embolism and Vascular Endothelial Growth Factor Inhibition.

Evandro M Neto-Neves et al.

The American journal of pathology, 187(4), 700-712 (2017-02-12)

Our understanding of the pathophysiological basis of chronic thromboembolic pulmonary hypertension (CTEPH) will be accelerated by an animal model that replicates the phenotype of human CTEPH. Sprague-Dawley rats were administered a combination of a single dose each of plastic microspheres

Mechanical ventilation strategies alter cardiovascular biomarkers in an infant rat model.

Philipp Baumann et al.

Physiological reports, 6(2) (2018-01-31)

Mechanical ventilation (MV) is routinely used in pediatric general anesthesia and critical care, but may adversely affect the cardiocirculatory system. Biomarkers are increasingly measured to assess cardiovascular status and improve clinical treatment decision-making. As the impact of mechanical ventilation strategies

Comparing effects of rest with or without a NK1RA on fibrosis and sensorimotor declines induced by a voluntary moderate demand task.

Mary F Barbe et al.

Journal of musculoskeletal & neuronal interactions, 19(4), 396-411 (2019-12-04)

Fibrosis is one contributing factor in motor dysfunction and discomfort in patients with overuse musculoskeletal disorders. We pharmacologically targeted the primary receptor for Substance P, neurokinin-1, using a specific antagonist (NK1RA) in a rat model of overuse with the goal

Potassium Channel Subfamily K Member 3 (KCNK3) Contributes to the Development of Pulmonary Arterial Hypertension.

Fabrice Antigny et al.

Circulation, 133(14), 1371-1385 (2016-02-26)

Mutations in the KCNK3 gene have been identified in some patients suffering from heritable pulmonary arterial hypertension (PAH). KCNK3 encodes an outward rectifier K(+) channel, and each identified mutation leads to a loss of function. However, the pathophysiological role of

MILLIPLEX^® Rat Vascular Injury Panel