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Human Mesenchymal Stem Cells (Bone Marrow)

Human mesenchymal stem cells derived from bone marrow that have a capacity for expansion in vitro while maintaining their potential for differentiation to multiple lineages including adipocytes, osteoblasts and chondrocytes.

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Synonym(s):
Human Bone Marrow MSCs, Human Bone Marrow Multipotent Stem Cells, Human MSCs
eCl@ss:
32011203
NACRES:
NA.75

biological source

human

Quality Level

100

technique(s)

cell culture | mammalian: suitable
cell culture | stem cell: suitable
cell differentiation: suitable

input

sample type mesenchymal stem cell(s)

shipped in

liquid nitrogen

Related Categories

General description

Mesenchymal stem cells, also known as marrow stromal cells, are defined as a self-renewing population of adherent, bone-marrow-derived multipotent progenitor cells with the capacity to differentiate into several mesenchymal cell lineages. In defined cultures in vitro, mesenchymal stem cells have been shown to readily differentiate into lineage-specific cells that form bone, cartilage, fat, tendon, and muscle tissues.

EMD Millipore’s Human Mesenchymal Stem Cells (Bone Marrow) are isolated from normal human bone marrow and are cryopreserved at P2 to ensure optimal phenotype and the highest viability and plating efficiency. These cells proliferate as an adherent cell monolayer and have shown a strong capacity for expansion in vitro while maintaining their potential for differentiation to multiple lineages including adipocytes, osteoblasts and chondrocytes..

Cell Line Description

Mesenchymal Stem Cells

Application

Research Category
Stem Cell Research

Components

1X106 viable Human Bone Marrow Mesenchymal Stem Cells

Quality

- Each vial contains at least 1X10⁶ viable cells at P2.
- Cell viability is greater than 75% at thaw and cells can be cultured for at least 3 population doublings after the initial thaw.
- Bone marrow donors tested negative for HIV, hepatitis B and hepatitis C.
- Apparently normal karyotype per cytogenetic analysis.
- Cells tested negative for mycoplasma contamination.

Storage and Stability

Human Mesenchymal Stem Cells (Bone Marrow) should be stored in liquid nitrogen. The cells are guaranteed for at least 3 population doublings without significantly affecting cell surface marker expression and differentiation potential.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

高风险级别生物产品--人源产品

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Sarah M Ridge et al.
Molecular cancer, 16(1), 31-31 (2017-02-06)
Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells, fibroblasts, cells of the immune system and mesenchymal stem
Jung Eun Lee et al.
Polymers, 11(5) (2019-05-08)
Human mesenchymal stem cells (hMSCs) show enormous potential in regenerative medicine and tissue engineering. However, current use of hMSCs in clinics is still limited because there is no appropriate way to control their behavior in vivo, such as differentiation to
Adam R Wolfe et al.
Oncotarget, 7(50), 82482-82492 (2016-10-21)
Inflammatory breast cancer (IBC) is a unique and deadly disease with unknown drivers. We hypothesized the inflammatory environment contributes to the IBC phenotype. We used an in vitro co-culture system to investigate interactions between normal and polarized macrophages (RAW 264.7
Edo Dzafic et al.
BioMed research international, 2014, 508216-508216 (2014-04-12)
After removal of oocytes for in vitro fertilization, follicular aspirates which are rich in somatic follicular cells are discarded in daily medical practice. However, there is some evidence that less differentiated cells with stem cell characteristics are present among aspirated
Niall J Logan et al.
Bone, 117, 149-160 (2018-09-17)
Trauma-induced heterotopic ossification is an intriguing phenomenon involving the inappropriate ossification of soft tissues within the body such as the muscle and ligaments. This inappropriate formation of bone is highly prevalent in those affected by blast injuries. Here, we developed
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Protocols

Mesenchymal Stem Cell Culture Protocols

Information about mesenchyme, specifically mesenchymal stem cell procotols. Step-by-step cell culture protocols for mesenchymal stem cell (MSC) isolation, expansion and differentiation.

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