MC38 Murine Colon Adenocarcinoma Cell Line

The most common form of colorectal cancer is adenocarcinoma which is responsible for an estimated 96% of colorectal cancers. Adenocarcinoma affects the glandular epithelial cells in the body. Risk factors include smoking, obesity, high alcohol consumption, poor diet, and other inflammatory bowel morbidities. A significant indication for colorectal cancer is the presence of colon polyps, which can take many years to become cancerous. This makes early screening particularly important for preventing cancer progression.

Adenomas are benign tumor polyps formed from the glandular epithelial cells that progressively develop molecular abnormalities until they eventually become metastatic and invasive cancers. Surgical removal is common for treating pre-malignant adenomas as well as advanced metastatic adenocarcinomas. Survival outlook is determined by disease progression at the time of diagnosis. Patients with metastasized colorectal adenocarcinoma have poor survival outlook, with a 5-year survival rate lower than 10%.

Source
The MC38 cell line was derived from a female C57BL/6 mouse.

References
Bioessays 2015, 37(8): 909-920.

Cancer Res 1975, 35(9): 2434-2439.

MC38 is relevant to the continued need to analyze colorectal adenocarcinoma progression, elucidating molecular alterations present in adenocarcinomas and how these mutations drive tumor progression. MC38 is an established and well-characterized model for colorectal cancer, exhibiting rapid growth and expressing colon markers claudin-1 and SATB. The MC38 cell line enables the study of genomic and epigenomic factors to identify colorectal adenocarcinoma treatment options.

MC38 cells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

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