DM6 Human Melanoma Cell Line

The DM6 human melanoma cell line is an established model for immunotherapy and chemoresistance. DM6 human melanoma cells harbor the melanoma driver mutation BRAF V600E and express the melanoma markers gp100 and MelanA (2). DM6 human melanoma cells express HLA-A2 antigen and are competent to induce T-cell cytotoxic response (3).The antigenic expression profile of this cell line has contributed to its utilization as a viable model for evaluating targeted cancer immunotherapy (4). DM6 melanoma cells are extremely resistant to the common first-line chemotherapy for malignant melanoma (5). The unique features of the DM6 human melanoma cell line make it a system with high clinical relevance.

Source:
The DM6 human melanoma cell line was derived from surgically excised lymph nodes dispersed into single cell suspensions (2).

Research Category:
Cancer

Human, Cancer Cells

≥1X10⁶ cells/vial

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Subject to local law, this product is intended to be sold for internal in vitro research use only subject to terms and conditions found here: www.sigmaaldrich.com/restrictedcelluse. This product may not be: re-engineered or copied; used to make derivatives, modifications or functional equivalents; used to obtain patents or other IP claiming use of the product; used to develop, test, or manufacturer a commercial product; used as a component in a commercial product; resold or licensed; used in any clinical applications or trials; or used in humans. A license or limited commercial use agreement is required for use by any for-profit entity, use in services, and use in sponsored academic research. For information regarding any such use, please contact licensing@milliporesigma.com.

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.