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3dGRO® Human Lung Organoids (PDXO.4056)

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Synonym(s):
Lung PDO;Lung Tumor Organoid;Airway Organoid;Pulmonary Organoid

biological source

human

Quality Level

100

packaging

vial of ≥ 1500 organoids/vial mg

manufacturer/tradename

Millipore

growth mode

N/A

technique(s)

cell culture | stem cell: suitable

shipped in

liquid nitrogen

storage temp.

−196°C

Application

  • Each vial contains >1500 organoids.
  • Mycoplasma: Negative
  • Genotyped by STR analysis: Pass
  • Human species verified
  • Organoids are negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses by PCR.
  • Cell viability test: Pass

Patient-derived lung organoids (lung PDOs) are adult tissue derived in vitro cultured “mini-lungs” that accurately replicate the histological and functional aspects of in vivo lung tissue. Lung organoids have been shown to contain all 6 major lung epithelial cell types including AEC2s, AEC1s, basal cells, club cells, goblet cells and ciliated cells. These 3D organoid models have become attractive alternatives to traditional PDX and animal lung models to study pulmonary diseases including COPD, cystic fibrosis, SARS-CoV-2, viral infections, asthma, and lung cancer. The 3dGRO® Human Lung Organoids are high quality cryopreserved cell lines derived from patient-derived xenografts, primary tumors or metastatic patient tissues from various regions of the human lung (acinar, papillary, solid, squamous, mucinous). These lung organoids are highly characterized and express lung airway markers including EPCAM, cytokeratin (CK5, CK7), acetyl-α-tubulin, surfactant proteins (SFTPB/SFTPC), TTF1, P63 and Muc5AC.

Cell Line Characteristics

Sex: Male
Age: 64
Organ: Lung (PDX- Solid)
Disease: Adenocarcinoma (Driver Mutations: cMET amplification)

Features and Benefits

Cryopreserved Male Adenocarcinoma Lung Organoids (Solid)

Storage and Stability

3dGRO® human lung organoids should be stored in liquid nitrogen.

Other Notes

3dGRO® is a trademark of KGaA, Darmstadt, Germany.3dGRO® organoids were derived utilizing HUB Organoid Technology.The purchaser of this product shall agree to HUB′s terms of use, which shall be separately acknowledged and accepted by such purchaser, prior to transfer of this product to purchaser.

Legal Information

3dGRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Lung Cancer Organoid Biobank

Explore our cryopreserved human lung organoid biobank from NSCLC tumor biopsies for lung cancer, SARS-CoV2, COPD and pulmonary disease research. Lung organoid 3D cell culture protocol available.

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