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Merck
CN

10107409001

Roche

Mitomycin C

crystalline powder, 98%, pkg of 2 mg

Synonym(s):

Mitomycin C

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About This Item

Empirical Formula (Hill Notation):
C15H18N4O5
CAS Number:
50-07-7
Molecular Weight:
334.33
MDL number:
MFCD00078109
UNSPSC Code:
12352207
NACRES:
NA.54

Key Documents

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Product Name

Mitomycin C, crystalline powder, 98%, pkg of 2 mg

SMILES string

N21[C@]([C@H]4N[C@H]4C2)([C@@H](C3=C1C(=O)C(=C(C3=O)N)C)COC(=O)N)OC

InChI

1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1

InChI key

NWIBSHFKIJFRCO-WUDYKRTCSA-N

assay

98%

form

crystalline powder

mol wt

334.3

packaging

pkg of 2 mg

manufacturer/tradename

Roche

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

Quality Level

100

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Application

Mitomycin C is used as an inhibitor for studies of cell-free protein biosynthesis. It also inhibits DNA synthesis. It has been used as a genotoxic agent for tumor cells.
Mitomycin C has been used:
  • to cease mitosis
  • in phosphate buffer saline (PBS) for inactivation and plating mouse embryonic fibroblasts (MEFs)
  • as mutagen in mutagenicity assay

Biochem/physiol Actions

Mitomycin C (MMC) acts as a prototype for drugs with bioreductive alkylation. It is mainly found to be active under anaerobic conditions. MMC exhibits a vast clinical antitumor spectrum effectively in gastric, pancreatic and breast cancer.

General description

Mitomycin C is an antitumor antibiotic.

Other Notes

For life science research only. Not for use in diagnostic procedures.

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

hcodes

H300,H351

Hazard Classifications

Acute Tox. 2 Oral - Carc. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
70020900
58287200
53267800
20240500
66178900

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Sertoli cell-mediated differentiation of bovine fetal mesenchymal stem cells into germ cell lineage using an in vitro co-culture system
Segunda MN, et al.
Theriogenology, 130, 8-18 (2019)
Natalia Garcia-Becerra et al.
Cancers, 15(2) (2023-01-22)
Cervical cancer (CC) is the fourth most common type of cancer among women; the main predisposing factor is persistent infection by high-risk human papillomavirus (hr-HPV), mainly the 16 or 18 genotypes. Both hr-HPVs are known to manipulate the cellular machinery
Jeremy Setton et al.
NPJ breast cancer, 7(1), 135-135 (2021-10-13)
Pathogenic germline mutations in the RAD51 paralog genes RAD51C and RAD51D, are known to confer susceptibility to ovarian and triple-negative breast cancer. Here, we investigated whether germline loss-of-function variants affecting another RAD51 paralog gene, RAD51B, are also associated with breast
Microbial Mutagenicity Assay: Ames Test
Vijay U, et al.
Bio-protocol, e3854-e3854 (2018)
Mitomycin C: mechanism of action, usefulness and limitations
Verweij J and Pinedo HM
Anti-Cancer Drugs, 1(1), 5-13 (1990)
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Articles

Antibiotic Kill Curve

Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic

抗生素杀灭曲线

抗生素杀灭曲线是一项剂量响应实验，通过逐渐增大施加在哺乳动物细胞中的备选抗生素剂量进行测定。

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