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About This Item
Empirical Formula (Hill Notation):
C6H11Na2O9P · xH2O
CAS Number:
Molecular Weight:
304.10 (anhydrous basis)
PubChem Substance ID:
UNSPSC Code:
12352302
Beilstein/REAXYS Number:
5199009
MDL number:
NACRES:
NA.54
SMILES string
O.[Na+].[Na+].OC1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H](O)[C@H]1O
InChI
1S/C6H13O9P.2Na.H2O/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8;;;/h2-10H,1H2,(H2,11,12,13);;;1H2/q;2*+1;/p-2/t2-,3-,4+,5-,6?;;;/m1.../s1
InChI key
UUWJZXLTPORJKW-WYFATIGWSA-L
form
solid
mol wt
(glucose-6-P: Mr = 260.2, glucose-6-P-Na2: Mr = 304.2)
packaging
pkg of 5 g
manufacturer/tradename
Roche
shipped in
ambient
Related Categories
General description
Disodium salt
Application
Substrate for glucose-6-phosphatase.
Biochem/physiol Actions
In mammals, glucose-6-phosphate (G6P) is formed by a kinase acting on glucose. It plays several roles and has its fate determined accordingly. It can get converted back to glucose by a phosphatase enzyme. It can pass into glycogen, or enter into the energy-yielding Embden-Meyerhof path or into the 6-phosphogluconate pathway. Increased levels of blood glucose result in elevated levels of glucose 6-phosphate in liver, skeletal muscle, and adipose tissue. This elevated intracellular level of G6P activates glycogen synthase. G6P may also be involved in the negative regulation of phosphorylation of glycogen synthase via cyclic AMP-stimulated protein kinase.
Preparation Note
77% glucose-6-P (enzymatic), 13% sodium, 8% water
C6H11O9PNa2
Analysis Note
Contaminants: <0.2% glucose (enzymatic)
Other Notes
For life science research only. Not for use in diagnostic procedures.
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
does not flash
flash_point_c
does not flash
Regulatory Information
涉药品监管产品
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C Villar-Palasí et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 11(7), 544-558 (1997-06-01)
Elevated blood glucose concentrations result in increased intracellular levels of glucose 6-phosphate in liver, skeletal muscle, and adipose tissue. In liver, blood glucose concentrations are the main factor in control of the synthesis of glycogen; insulin has only a potentiating
THE ROLE OF GLUCOSE 6-PHOSPHATE IN THE REGULATION OF GLUCOSE METABOLISM IN HUMAN ERYTHROCYTES.
I A ROSE et al.
The Journal of biological chemistry, 239, 12-17 (1964-01-01)
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